Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Studies have highlighted important features of the nucleocytoplasmic transport of mRNAs and proteins.
Nuclear RNA export factor 3
(
NXF3
) is a member of the nuclear RNA export factor family that plays a role in mediating the export of cellular mRNA from the nucleus to the cytoplasm for translation. However, little is known about the clinical significance of
NXF3
in human tumors. To evaluate the prognostic significance of
NXF3
in
hepatocellular carcinoma
(
HCC
), the expression levels of
NXF3
in a cohort of 112 patients with primary
HCC
who had undergone hepatectomy for histologically confirmed
HCC
were assessed by immunohistochemistry. It was identified that the expression levels of
NXF3
were higher in the primary
HCC
tissues compared with those in paired peritumoral liver tissues. The overexpression of
NXF3
in the
HCC
tissues was correlated with decreased survival time [hazard ratio (HR) = 1.954, 95% confidence interval (CI) = 1.034-3.695, P=0.039] and earlier tumor recurrence (HR = 2.101, 95% CI = 1.186-3.722, P=0.011) in postoperative patients with
HCC
. Notably, overexpression of
NXF3
was correlated with a poor survival time and increased recurrence following
HCC
resection in male patients (P=0.020 and P=0.007, respectively) but not in female patients (P=0.916 and P=0.821, respectively). In conclusion, the findings provide evidence that implicates
NXF3
as a prospective predictor of
HCC
prognosis as well as a potential therapeutic target for cancer treatment.
...
PMID:Prognostic significance of nuclear RNA export factor 3 in hepatocellular carcinoma. 2452 Feb 86
Various studies revealed that numerous long noncoding RNAs (lncRNAs) have been found dysregulated in
HCC
and played important role in hepatocarcinogenesis, although the underlying mechanism still remains unclear. Herein, we reported AF119895, a new lncRNA which was identified from microarray and amplified in
HCC
. Functionally, AF119895 promoted migration and invasion of
HCC
cells both in vitro and in vivo. Furthermore, we identified that
NXF3
was a downstream target of AF119895.
NXF3
depletion could decrease
HCC
cells migration and invasion. In addition, AF119895 could act as an endogenous sponge by binding to miR-6508-3p and reduce miR-6508-3p expression. And miR-6508-3p could regulate
NXF3
by interacting with its 3'UTR. These observations collectively demonstrate that AF119895 modulates the repression of
NXF3
by binding to miR-6508-3p. Our results outline a novel signaling pathway mediated by AF119895 and suggest its candidacy as a new prognostic biomarker and therapeutic target of
HCC
.
...
PMID:AF119895 regulates NXF3 expression to promote migration and invasion of hepatocellular carcinoma through an interaction with miR-6508-3p. 2927 23
