Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It has been demonstrated that loss of heterozygosity (LOH) was frequently observed on chromosomes 8p22-p23 in
hepatocellular carcinoma
(
HCC
) and was associated with metastasis and prognosis of
HCC
. However, putative genes functioning on this chromosomal region remain unknown. In this study, we evaluated LOH status of four genes on 8p22-p23 (MCPH1, TUSC3,
KIAA1456
, and ZDHHC2). LOH on ZDHHC2 was associated with early metastatic recurrence of
HCC
following liver transplantation and was correlated with tumor size and portal vein tumor thrombi. Furthermore, our results indicate that ZDHHC2 expression was frequently decreased in
HCC
. Overexpression of ZDHHC2 could inhibit proliferation, migration, and invasion of
HCC
cell line Bel-7402 in vitro. These results suggest an important role for ZDHHC2 as a tumor suppressor in metastasis and recurrence of
HCC
.
...
PMID:A critical role for ZDHHC2 in metastasis and recurrence in human hepatocellular carcinoma. 2499 31
