Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Background:
Hepatocellular carcinoma
(
HCC
) is the third leading cause of cancer-related mortality worldwide. The poor survival may be due to tumor recurrence and metastasis. Growing evidence indicates that Leucine Zipper Transcription Factor-like 1 (
LZTFL1
) plays an important role in tumor progression of several cancers such as lung cancer and gastric cancer.
Methods:
Real-time PCR was performed to evaluate
LZTFL1
expression level in
HCC
cell lines and patient specimens. The relationship between
LZTFL1
expression and the clinicopathological data of the patients was analyzed. Stable cell lines with overexpressing
LZTFL1
were set-up, and the cell proliferation, migration, and invasion abilities were analyzed. The protein expression was measured by Western blotting.
Results:
Here, we found
LZTFL1
expression was decreased in human
HCC
specimens and
HCC
cell lines. Downregulation of
LZTFL1
expression was correlated with tumor stage and metastasis. The ectopic overexpression of
LZTFL1
inhibited cell proliferation, migration, invasion, and the expression of MMP9. In addition,
LZTFL1
suppressed epithelial mesenchymal transition (EMT).
Conclusion:
Taken together, our results highlight the tumor suppressive role of
LZTFL1
in
HCC
, suggesting that
LZTFL1
may represent a potential therapeutic strategy for treating patients with
HCC
.
...
PMID:Tumor suppressive functions of LZTFL1 in hepatocellular carcinoma. 3137 91
