Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019204 (hepatocellular carcinoma)
 71,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of 2 new modified actinomycins was studied. Actinomycin AuGl had the residue of sarcozin replaced by glycine and actinomycin AuNv had 1 residue of norvaline. It was shown that the new actinomycins had a similar to the actinomycin type effect on the microbial and animal cells. Still, higher concentrations of the antibiotics were required. In concentrations equal to those of actinomycins the new antibiotics were less effective with respect to the bacteriostatic action, suppression of the RNA synthesis and mitotic division of the ascitic hepatoma 22A cells.
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PMID:[Biological properties of the modified actinomycins synthesized by the aurantin producer]. 7 11

The article describes the case of a 42 year old woman who died of liver cell carcinoma; the woman had been on oral contraceptives (OCs) for 10 years. The association between OCs and liver cancer is being reported more and more frequently. Still, it is not clear exactly which is the mechanism that causes the malignant tumor. If coincidence and preexisting tumor are ruled out, it is possible that OCs, diminishing biliar excretion, help the accumulation of carcinogenetic substances.
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PMID:[Liver cell carcinoma associated with oral contraceptives (author's transl)]. 20 78

Significant salvage of patients with a wide variety of cysts and benign tumors of the liver and of some patients with biliary strictures can be achieved by hepatic resection in carefully selected clinical situations with a low operative mortality rate and an acceptable postoperative complication rate. Still to be determined is the role of hepatic resection in metastatic carcinoma and sarcoma of the liver, where survival is modest but measurable, but important palliation can be achieved. Hepatomas should be resected when possible, but hepatic resection for aid in resection of bile duct carcinoma has proved generally unrewarding.
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PMID:Elective hepatic resection. 21 70

The dissociation of insulin from its receptor has been reported to be enhanced in the presence of unlabeled insulin. This phenomenon has been used as a proof for the existence of negative cooperativity. However, when insulin degradation was inhibited by the use of a combination of bacitracin and chloroquine or prevented by a short incubation time in insulin binding studies in H35 rat hepatoma cells, linear Scatchard plots were obtained. This indicates that in the absence of insulin degradation negative cooperativity does not occur in these cells. Still the dissociation of insulin from its receptor was enhanced in the presence of 167 nM unlabeled insulin. This seriously questions the use of demonstration of insulin induced enhancement of insulin dissociation from its receptor as proof for the existence of negative cooperativity.
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PMID:Demonstration of insulin induced enhancement of insulin dissociation from its receptor in H35 rat hepatoma cells in spite of a linear Scatchard plot. 181 84

Hepatocellular carcinoma is different from other solid tumors. Because of concomitant cirrhosis or multiple lesions, most hepatocellular carcinoma is unresectable. Still worse, hepatocellular carcinoma frequently recurs after surgical resection; the 5-year cumulative recurrence rate is 70-90% even after curative hepatectomy. The situation is similar in small hepatocellular carcinoma 2 cm or less in diameter. Thus, non-surgical treatment plays an important role. At present, we think that percutaneous ethanol injection therapy (PEIT) is best for the treatment of hepatocellular carcinoma because of its local curativity, minimal adverse effect on liver function, and the easy feasibility of repeated treatment for recurrence. We have recently treated about 85% of hepatocellular carcinoma cases by PEIT and have achieved satisfactory long-term results. Here we describe our results in PEIT for small hepatocellular carcinoma. By the end of December 1995, we performed PEIT on 410 patients with hepatocellular carcinoma. Among them, 140 patients were diagnosed as having small hepatocellular carcinoma 2 cm or less in diameter. The 1-, 3-, 5-, 7-, and 10-year survival rates of the 140 patients were 93%, 73%, 55%, 51%, and 32%, respectively. Furthermore, in 83 patients who had a single, small hepatocellular carcinoma 2 cm or less in diameter, the 1-, 3-, 5-, 7-, and 10-year survival rates were 92%, 82%, 72%, 66%, and 66%, respectively. Thus PEIT achieved satisfactory long-term survival rates in the treatment of small hepatocellular carcinoma.
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PMID:[Percutaneous ethanol injection therapy for small hepatocellular carcinoma]. 867 30

Chronic alcoholism in patients with chronic hepatitis C hastens disease progression toward development of cirrhosis and hepatocellular carcinoma. Approximately 30% of alcoholic patients with liver disease are infected with the hepatitis C virus (HCV), the primary risk factor being a history of injection drug use. The histologic pattern in alcoholics is typically indistinguishable from nonalcoholic patients similarly infected with chronic hepatitis C. The mechanism(s) involved in alcohol-induced enhancement of chronic hepatitis C have not entirely been established but may involve increased viral replication, iron overload, and immune suppression. Still to be determined is the minimum amount of daily alcohol intake, if any, that can be ingested without enhancing progressive liver injury. However, chronic hepatitis C patients undergoing treatment with interferon must abstain from any alcohol intake, because the efficacy of interferon therapy is significantly lower in those who continue to drink. Future research efforts are needed in order to further delineate the epidemiology and pathogenesis of chronic hepatitis C in the alcoholic patient.
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PMID:The alcoholic patient with hepatitis C virus infection. 1065 67

Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver. Although several therapeutic options have been advocated, transcatheter arterial chemoembolization (TACE) in particular has been widely performed in the treatment of HCC. Still, hepatic arteriography and portography are mandatory for evaluation of (a) the resectability and multiplicity of HCCs and (b) the hemodynamic status of the portal vein. Thereafter, TACE can be considered as the initial therapeutic modality. The possibility of nontarget organ complications during TACE (eg, ischemic cholecystitis, splenic infarction, gastrointestinal mucosal lesions, pulmonary embolism and infarction, spinal cord injury, ischemic skin lesions) should be taken seriously. A thorough understanding of the anatomic variants and hemodynamic features of the hepatic artery and portal vein is the first step in performing effective and safe TACE for HCC.
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PMID:Transcatheter arterial chemoembolization for hepatocellular carcinoma: anatomic and hemodynamic considerations in the hepatic artery and portal vein. 1223 37

Hepatocellular carcinoma (HCC) is an increasingly frequent cause of mortality in hemophiliacs with chronic viral hepatitis. Early diagnosis of the tumor at an initial stage is known to improve the outcome of HCC treatment. Because all HCC cases detected in a previous study based upon annual ultrasound (US) surveillance of hemophiliacs with elevated alanine aminotransferase levels were multinodular, this study was designed to evaluate if a more intense surveillance with US and alphafetoprotein (AFP) serum levels of all the patients infected with the hepatitis C virus (HCV) improved the identification of single nodule tumors. A multicenter cohort of 559 HCV-infected hemophiliacs was divided into 2 arms, one followed up at 6-month intervals and one at 12-month intervals depending on the choice and available facilities of each treatment center. During a 6-year surveillance period, HCC was diagnosed in 5 (2.4%) of 210 patients in the 6-month group and in 3 (0.9%) of 349 patients in the 12-month group. The overall incidence rate of HCC was 239 per 100 000 per year (397 per 100 000 per year in the 6-month group and 143 per 100 000 per year in the 12-month group; differences not statistically significant). By multivariate analysis, HCC risk was increased 12.9-fold with alcohol intake more than 80 g/d and 15.2-fold with AFP levels higher than 11 ng/mL. Liver-related death occurred in 8 cases (1.4%), including 3 with HCC. Still alive and tumor free after 24 to 34 months from diagnosis are 3 patients with multinodular tumors treated with repeat chemoembolization followed by orthotopic liver transplantation. In conclusion, 6-month surveillance with US did not increase the chances of detection of single nodule tumors, but it is reasonable to assume that successful treatment of multinodular tumors based upon debulking with chemoembolization and liver transplantation was facilitated by this approach.
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PMID:A 6-month versus a 12-month surveillance for hepatocellular carcinoma in 559 hemophiliacs infected with the hepatitis C virus. 1264 65

Still, very little is known about the precise pathogenetic mechanisms, the triggering events and in particular, the evolution and treatment of nonalcoholic steatohepatitis (NASH). It is part of the broad spectrum of nonalcoholic fatty liver diseases (NAFLDs). Mainly, it has been reported as a benign disease, associated with metabolic disorders commonly occurrence en the general population. Nevertheless, the syndrome can lead to cirrhosis, liver failure or hepatocellular carcinoma, requiring liver transplantation. We present one patient with diagnosis of NASH, who was treated initially for overweight, HTA and hyperlipaemia with incompleted response and who showed a quickly progress to cirrhosis but no cause of liver decompensated disease could be identified. Currently she is at end-stage waiting a liver transplantation. Controlled and multicentric studies with the same definition of NASH and the study end-points are needed, and will provide information about diagnosis features and novel therapies to early management of the disease.
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PMID:[Nonalcoholic steatohepatitis, the enigma of bad progression]. 1589 87

This article reviews the current status of local ablation therapy for hepatocellular carcinoma HCC. In the treatment of HCC, non-surgical treatments play important roles since only 20-30% of patients are candidates for surgery. Still worse, even after curative surgical resection, 80% of patients develop recurrence within 5 years. Among non-surgical treatments, image-guided local ablation therapies have been widely used for cases of small-number and small-size lesions, because they are potentially curative, minimally invasive, and easily repeatable. Although percutaneous ethanol injection has long been a standard therapy, there has been a drastic shift from ethanol injection to radiofrequency ablation in recent years. Randomized controlled trials proved that radiofrequency ablation is superior to ethanol injection in the treatment of HCC from the viewpoint of not only treatment response but also long-term survival. Radiofrequency ablation will play more important roles in the treatment of HCC.
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PMID:Local ablation therapy for hepatocellular carcinoma. From ethanol injection to radiofrequency ablation. 1753 94


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