Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Nuclear receptor coactivator 5
(
NCOA5
) plays important roles in the development of a variety of malignancies. However, the underlying mechanisms remain obscure. In this study, we successfully generated the
NCOA5
knockout
hepatocellular carcinoma
(
HCC
) cells by CRISPR/Cas9 - mediated genome editing and found that knockout of
NCOA5
inhibited the proliferation and tumor microsphere formation of
HCC
cells significantly. Moreover, the migration ability of
NCOA5
knockout
HCC
cells declined. Mechanistic analyses indicated that knockout of
NCOA5
can suppress the epithelial - mesenchymal transition (EMT) in
HCC
cells. In conclusion, our findings provide a mechanistic insight into the role of
NCOA5
in
HCC
progression.
...
PMID:Knockout of NCOA5 impairs proliferation and migration of hepatocellular carcinoma cells by suppressing epithelial-to-mesenchymal transition. 2962 78
