Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019204 (hepatocellular carcinoma)
 71,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Of 190 sets selective celiac and/or hepatic angiograms obtained in patients with hepatocellular carcinoma (HCC), comparison with gross anatomy of the liver was subsequently made by autopsy in 77 and by surgery in 23. It was found that the gross anatomy of HCC can be assessed with certain accuracy by careful interpretation of the angiograms, because tumor vasculature and vascular alterations in the noncancerous parenchyma are closely related to the mode of tumor growth, size of tumor nodules and their distribution. Even a fibrous capsule of the tumor may be discerned as a radiolucent zone around the tumor contour. Diagnosis of the gross anatomical type of HCC is important to the selection of therapeutic measure and assessment of prognosis.
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PMID:Angiographic assessment of gross anatomy of hepatocellular cardinoma: comparison of celiac angiograms and liver pathology in 100 cases. 19 72

A single injection of N-methyl-N-nitrosourea results in simultaneous long-term inhibition of tumor growth and protein synthesis in mouse hepatoma 22a cells. These effects are tightly connected: onset of tumor regrowth starts only after a full recovery of the activity of the protein synthetic machinery of tumor cells.
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PMID:[Tumor growth and protein synthesis in mouse hepatoma 22A cells under antitumor effect of N-methyl-N-nitrosourea]. 19 42

A total of 141 patients with hepatocellular carcinoma were examined by selective celiac and hepatic arteriography. In 7 the so-called "thread and streaks" sign or its equivalent was observed along the vertebral column at the level of the diaphragm where the hepatic veins enter the inferior vena cava. Extensive tumor growth in the hepatic vein and invading the vena cava was confirmed by autopsy in 3 and hepatic venography in 1.
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PMID:Angiographic demonstration of growth of hepatocellular carcinoma in the hepatic vein and inferior vena cava. 19 76

Intraperitoneal injection of trace amounts of corn oil prior to and following the injection of 40-50 mg of tissue from hepatoma 7777 or 7800 into the thigh of adult male Buffalo rats resulted in a marked decrease in the growth rate of both tumors. Exhaustive extraction of the corn oil with water indicated that the active component was not water soluble. Similar injections of safflower oil or isotonic saline had no effect on tumor growth rate. Analysis of the tissue phospholipid fatty acids revealed that the injected corn oil caused no change in the esterified fatty acids in this lipid fraction.
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PMID:Inhibition of growth of Morris hepatomas 7777 and 7800 by corn oil. 19 60

Hematological studied were carried out serially in the rats transplanted subcutaneously with Yoshida ascites hepatoma AH-109A. Significant changes were observed in fibrinogen level, fibrinogen degradation products, recalcification time, platelet count, and fragmentation of red blood cells. Formation of thrombi was revealed in the vessels of tumor tissue morphologically from early stage when the tumor grew to a palpable size. Thrombi were formed also in the arterioles of the lungs in the terminal stage. Bleeding tendency was noted in some cases at death. These findings suggested the experimental induction of a type of disseminated intravascular coagulation. The systemic changes of the blood occurring in the terminal stage were preceded by localized intravascular coagulation and fibrinolysis in the tumor in early stage of tumor growth.
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PMID:Hematological alterations in tumor-bearing rats, with reference to pathogenesis of chronic type of disseminated intravascular coagulation syndrome. 20 34

Aprotinin, a wide range proteinase inhibitor, was given alone to tumor-bearing mice and life span and several tumor growth parameters were recordered. Aprotinin showed anti-tumor effects in Hepatoma 22 and Lewis lung carcinoma, remaining ineffective in Sarcoma 37, Leukemia L1210 and Ehrlich ascitic carcinoma.
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PMID:Effect of proteinase inhibitor in experimental tumors. 20 10

The effect of intradermal immunisation with viable line 1 hepatoma cells and BCG was studied in syngeneic strain 2 guinea pigs. Immunisation with 1.5 X 10(6) hepatoma cells admixed to 200 microgram BCG induced tumor regression in 7/8 animals. Higher or lower doses were less effective and sometimes led to enhanced tumor growth. It appeared that regression or progression of tumors is established as early as 3 weeks after tumor inoculation. Aspects of humoral and cell-mediated tumor immunity in immunised and/or tumor-bearing animals were studied in vitro by the use of mixed cell cultures and of cytotoxicity tests. Immunised tumor-bearing animals reacted more vigorously than those from non-immunised animals when the tumor was small. With increasing tumor volume the specific tumor immunity disappeared in both immunised and non-immunised animals. Sera obtained from immunised or regressor animals were cytotoxic and partially blocked the mixed cell interaction. Sera obtained from progressor animals were neither cytotoxic and nor did they block the mixed cell interaction. Cytotoxic activities resided within immunoglobulin fractions enriched in IgG1 or IgG2, whereas blocking activity was mainly associated with IgG2. The effector cell function was not inhibited by the immunoglobulin fractions tested. In the discussion it is suggested that the ratio of IgG1 and IgG2 antibodies elicited during immune treatment may critically influence the success or failure of immunotherapy.
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PMID:Immunotherapy with tumor cells and BCG in the guinea pig, studied by immunological in vivo and in vitro experiments. 20 79

To evaluate the effects of oral and intravenous nutritional repletion on tumor growth and host immunocompetence in malnourished animals, 60 adult purified protein derivative (PPD) positive Buffalo rats were inoculated with Morris hepatoma 5123 and were fed a regular diet for 14 days. All animals then were switched to a high carbohydrate, protein-free diet for the next 14 days, at which time only 30% of the animals remained PPD positive. Rats then were divided into three groups: group I underwent superior vena cava catheterization and received a constant infusion of 25% dextrose--4.25% amino acid solution; group II was switched to the regular protein diet orally ad libitum; and group III remained on the oral protein-free diet. PPD reactivities were measured prior to death 7 days later. Group I animals gained an average of 14 gm of body weight, and 91% of the animals were PPD positive. Group II animals lost an average of 17 gm of body weight, but 78% of the animals were PPD positive. Group III animals lost an average of 23 gm of body weight, and only 12% of the animals remained PPD positive. Absolute tumor weight and tumor weight: body weight ratios were not significantly different among the three groups of animals. Provision of adequate nutrition intravenously to malnourished tumor-bearing animals restores body weight and host immunocompetence without adversely stimulating tumor growth out of proportion to growth of the host.
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PMID:Effects of intravenous nutrition on tumor growth and host immunocompetence in malnourished animals. 21 54

Direct cholangiography revealed 6 cases of hepatoma where tumor growth within the bile ducts caused obstructive jaundice. Characteristic features included bulky obstructing intraluminal masses in the proximal extrahepatic ducts. Distal common duct defects usually signify hemobilia and clots as tumor complication. Review of the literature disclosed only 22 cases in which common duct involvement was a predominant clinical feature. Hepatoma should be included in the different diagnosis of a cholangiographic filling defect in the proximal extrahepatic bile ducts. The recent widespread use of endoscopic and fine needle transhepatic cholangiography should aid in preoperative diagnosis.
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PMID:Bile duct obstruction in hepatocellular carcinoma (hepatoma)--clinical and cholangiographic characteristics. Report of 6 cases and review of the literature. 21 14

Cardiac output, regional tissue and arterial tumor blood flow were studied in rats, with 99Tcm labelled microspheres using a reference sample simultaneously drawn as the spheres were injected. Both cardiac output and regional blood flow can be estimated in absolute values (ml X min-1 X g-1). Cardiac output and normal tissue blood flow were not affected by tumor growth in the liver or subcutaneously. In small tumors total blood flow was inversely proportional to tumor size, a finding similar in all 3 tumors studied. A relation found in liver as well as in subcutaneously implanted tumors. Blood flow in subcutaneous tumors was greater than muscle or skin blood flow. BP sarcoma had higher blood flow than the hepatoma and the adenocarcinoma. In big tumors the peripheral blood flow was larger than that in the centre of the tumor.
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PMID:Measurements of total and regional tumor blood flow and organ blood flow using 99Tcm labelled microspheres. An experimental study in rats. 21 51


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