Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
This study aimed to identify key functional modules and genes in functional module involved in
hepatocellular carcinoma
(
HCC
) development. The microarray data set GSE54236 was obtained from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) between
HCC
, and normal samples were identified by Limma. DAVID was used to identify the gene ontology terms these genes enriched. The co-expression network was constructed based on Pearson correlation coefficient between gene expression values, and the functional modules these DEGs obviously enriched in were recognized through GraphWeb. Then, based on the genes related to the development of
HCC
, the DEGs interacting with
HCC
-associated genes were spotted. Finally, survival analysis and real-time quantitative polymerase chain reaction were performed. Totally, 427 upregulated (e.g.,
cell division cycle associated 5
[
CDCA5
], kinesin family member 4A [
KIF4A
], TPX2 microtubule nucleation factor [
TPX2
]) and 313 downregulated (e.g., metallothionein 1E [
MT1E
]) DEGs were identified in
HCC
. Besides,
CDCA5
,
KIF4A
, and
TPX2
had interacting relationship and played important roles in
HCC
development by interrelating with
HCC
-related gene, forkhead box M1 (
FOXM1
). Furthermore,
CDCA5
,
KIF4A
,
TPX2
, and
FOXM1
obviously enriched in cell cycle-related functional module, whereas
MT1E
enriched in mineral absorption module in Kyoto Encyclopedia of Genes and Genomes.
CDCA5
,
KIF4A
, and
TPX2
expression were increased in
HCC
cells, and their high expressions were related to poor prognosis. Overexpression of
CDCA5
,
KIF4A
,
TPX2
, and
FOXM1
coregulated cell cycle and thereby promoted the development of
HCC
. The finding provided potential targets for the study and treatment of
HCC
.
...
PMID:Overexpression of
CDCA5
,
KIF4A
,
TPX2
, and
FOXM1
Coregulated Cell Cycle and Promoted Hepatocellular Carcinoma Development. 3159 90
