Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019204 (hepatocellular carcinoma)
 71,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The frequency of anti-HBe and the effects of alcohol on the liver were serologically and histologically assessed in 28 nondrinking HBsAg carriers (group I), 33 mildly drinking HBsAg carriers (group II), and 21 moderately to heavily drinking HBsAg carriers (group III). The frequency of anti-HBe was significantly different in these groups (p less than 0.001). The frequency of chronic active hepatitis was significantly less in group III than in groups I or II (p less than 0.05). The frequency of HBeAg-positive carriers with chronic hepatitis was significantly less in group III (p less than 0.02). Histologically, the patients in group II mainly showed viral hepatic changes, whereas the patients in group III chiefly revealed alcoholic changes. Micronodular cirrhosis and hepatocellular carcinoma were seen in group III alone. These results suggest that increasing alcohol consumption is related to increasing prevalence of seroconversion from HBeAg to anti-HBe and to increasing prevalence of alcoholic liver disease and decreasing prevalence of chronic hepatitis.
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PMID:Effects of alcohol on the liver in HBsAg carriers. 375 40

The spectrum of histological changes in needle biopsies of the liver tissue was analysed in 43 patients with chronic liver disease who were positive for hepatitis B surface antigen (HBsAg) in their sera. Majority of the patients were around 40 years and there was a male predominance. According to histopathological pattern, there were 18 (41.8%) cases of chronic active hepatitis, 16 (37.2%) cases of inactive cirrhosis, 3 (6.9%) cases of chronic persistent hepatitis and 2 (4.7%) cases of chronic lobular hepatitis and hepatoma each. Two (4.7%) cases could not be exactly categorised into any particular histological entity. The inflammation, hepatic cell necrosis and fibrosis were more marked in cases of chronic active hepatitis without past history of jaundice. Micronodular cirrhosis was the most common histological pattern in the study. Shikata orcein stain for detection of HBsAg in the hepatocytes was positive in 8 (18.6%) cases only.
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PMID:Hepatic histology in chronic liver disease in hepatitis B surface antigen positive cases. 782 48

This study aims at establishing the pattern of liver cirrhosis. Histology slides and duplicate copies of reports were retrieved and re-examined while fresh sections were processed from original paraffin blocks when necessary. Cirrhosis was the second commonest cause of chronic liver disease after hepatocellular carcinoma. The commonest morphological type was macronodular cirrhosis. Micronodular cirrhosis is not as common in black Africans as among the Caucasians. This is not unexpected since alcoholic liver disease that is of aetiopathogenetic importance is also not as common as what is often found in Causasians. Biliary cirrhosis was reported in an 8 months old girl consequent upon congenital absence of gallbladder and biliary tree. There was male preponderance in the occurrence of cirrhosis with a male, female ratio of 2.5:1. The incidence gradually increased from early adult life but was highest in the middle age especially between the age group of 51-60 years and subsequently dropped sharply. Adequate diagnostic facilities should be provided to determine the incidence of hepatotropic viruses and their contribution to the incidence of chronic liver diseases. Case-controlled studies should be carried out to determine the role of local cultural practices on hepatocellular injury and the development of chronic liver disease.
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PMID:Histopathological assessment of the pattern of liver cirrhosis in a tropical population. 1502 82