Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019204 (hepatocellular carcinoma)
 71,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Necropsy and clinical data show that primary hepatocellular carcinoma (PHC) is the commonest cancer among the Senoi (a Malaysian aboringine group). The other aboringine tribes do not appear to have this high predilection for liver cancer. In the necropsy series, PHS was present in 10 out of 22 Senoi patients with cirrhosis. All the 22 livers contained hepatocytes that stained with Shikata's orcein stain and specific immunoperoxidase and immunofluorescent stains for hepatitis B antigen (HBAg). This observation raises the strong possibility that hepatitis B may be an important etiologic factor in the development of cirrhosis and PHC in the Senoi. The reason for the high susceptibility of the Senoi for HB virus infection is not clear, and the role of aflatoxin in the pathogenesis of PHC in the Senoi has yet to be determined. That the Senoi are a numerically small community, maintaining their own unique dietary and social customs and living in readily accessible areas in the Malaysian jungle, makes them an ideal population for the study of factors in the etiology of liver cancer.
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PMID:HBAg-positive chronic liver disease associated with cirrhosis and hepatocellular carcinoma in the Senoi. 19

The liver-specificity of insulin-like growth factor binding protein-1 (IGFBP-1) gene promoter activity has been studied by transient transfection in rat hepatoma cell lines, rat fibroblasts and human cervical carcinoma cells, and shown to be dependent on HNF1. Regulation of IGFBP-1 gene expression has also been studied in rat liver by Northern blot and run-on assays during development, specifically during the perinatal period. The results suggest (1) that the increases in mRNA at birth and +1 day post-natally result from increased transcription and (2) that no decrease in transcription activity accompanies the rapid IGFBP-1 mRNA decay during the neonatal period, arguing for post-transcriptional regulation. Support for transcriptional regulation during the neonatal period was obtained from in vitro footprinting experiments and gel shift data. Three trans-acting factors interact with the h-IGFBP-1 promoter between nt -265 and -305. Two of these, Pc and PHS, were expressed throughout development, as well as during adulthood, and interacted with cis-elements spanning nt -295 to -305 and -265 to -285, respectively. The third, Pa, was expressed only when IGFBP-1 gene expression was high, and interacted with cis-elements spanning nt -285 to -295.
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PMID:Characterization of cis-acting elements and transacting factors involved in the tissue-specific and developmental regulation of IGFBP-1 gene expression. 768 17