Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Lack of insight
into the mechanisms underlying
hepatocellular carcinoma
(
HCC
) metastasis has hindered the development of curative treatments. Overexpression of interleukin-13 receptor alpha 2 (IL13RA2) has been reported to contribute to invasion and metastasis in several tumors. However, the role of IL13RA2 in
HCC
remains to be characterized. In this study, we identified that low expression of IL13RA2 is associated with poor survival of patients with
HCC
, and demonstrated that IL13RA2 knockdown endows
HCC
cells with invasive potential. Mechanistically, silencing of IL13RA2 promotes partial epithelial-mesenchymal transition via increasing extracellular signal-regulated kinase phosphorylation in
HCC
. Collectively, our results suggest that IL13RA2 may have potential as a prognostic biomarker for
HCC
.
...
PMID:Silencing of IL13RA2 promotes partial epithelial-mesenchymal transition in hepatocellular carcinoma via ERK signaling pathway activation. 3182 84
