Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019204 (hepatocellular carcinoma)
 71,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report two cases of giant hepatic angiomyolipoma with a prominent component of epithelioid smooth muscle cells exhibiting a distinctive trabecular arrangement. These cells possessed peripherally vacuolated and centrally condensed hyaline cytoplasm. The nuclei were eccentrically placed in the cytoplasm. Immunohistochemically, they expressed HMB-45 intensely in the central condensed cytoplasm and actin in a perimembranous fashion. Staining for desmin, myoglobin and vimentin was negative. HMB-45 may prove to be a sensitive marker for angiomyolipoma with epithelioid cells. Hepatocellular carcinoma and other hepatic tumours with polygonal clear cells can be readily distinguished by these means.
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PMID:Hepatic angiomyolipomas with a deceptive trabecular pattern and HMB-45 reactivity. 133 41

We describe the sonographic, CT and angiographic findings in 10 cases of hepatocellular carcinoma in which extensive fatty metamorphosis occurred within the tumors. Fatty change was diffuse in smaller tumors (less than 3.5 cm) and focal in larger tumors (greater than 3.5 cm). Fatty metamorphosis characteristically caused a low-attenuation area on CT (less than -10 H) and a highly echogenic area on sonography. The sonographic appearance of small hepatocellular carcinomas with fatty metamorphosis was identical to the findings in cavernous hemangioma or focal fatty change of the liver. CT correctly revealed the presence of fat in these hepatocellular carcinomas. In these cases, hepatic arteriography showed no tumor stain; however, CT arteriography (dynamic CT during injection of contrast medium into the hepatic artery) was useful in showing the tumor, its capsule, and its internal septa. In the diagnosis of large hepatocellular carcinoma, the presence of intratumoral fat is not likely to be problematic, but small tumors that are diffusely infiltrated by fat must be distinguished from such benign conditions as focal fatty change, lipoma, and angiomyolipoma.
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PMID:Fatty metamorphosis in hepatocellular carcinoma: radiologic features in 10 cases. 284 71

The presence of fat in hepatic masses narrows the range of differential diagnoses down to hepatic angiomyolipoma, lipoma, adenoma, hepatoma, metastatic fatty tumors of the liver, focal fatty infiltration of the liver, and extrahepatic fatty masses such as intraperitoneal implants from malignant teratomas, and packed omentum. We report six hepatic tumors containing fat (lipoma, hepatocellular carcinoma, and calcified mass with fat-fluid level) with CT and magnetic resonance (MR) imaging. The distribution of fat was diffuse in the lipomas and some hepatocellular carcinomas and localized in other hepatocellular carcinomas and fat-fluid masses. The density ranged from - 100 to 0 HU. High intensity areas on both T1- and T2-weighted MR images corresponded to the hypodense areas on CT.
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PMID:CT and MR imaging of fatty tumors of the liver. 302 96

Angiomyolipomas of the liver are rare benign tumours. We describe the variable imaging appearances of these tumours in three women. The first two patients underwent ultrasound, computed tomography (CT) and angiography, which demonstrated lesions resembling focal nodular hyperplasia and hepatocellular carcinoma, respectively. Both had histologically-proven liver angiomyolipomas surgically resected. The third patient was incidentally found to have typical features of multicomponented liver angiomyolipoma on CT. Variable proportions of fatty tissue in these tumours are the most likely explanation for their different imaging appearances on CT.
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PMID:Case report: variable imaging appearances of angiomyolipomas of the liver. 778 45

Angiomyolipoma (AML) of the liver is extremely rare; we believe only about 60 cases, all solitary, have been reported. We present here the first reported case, to our knowledge, of multiple AMLs in the liver. Two masses were found in the liver of a 43-year-old Japanese woman complaining of abdominal discomfort by ultrasonography and computed tomography. With a preoperative diagnosis of hepatocellular carcinoma, a tumor in the right lobe 4.0 cm in largest diameter and one in the left lobe measuring 2.4 cm were resected. Histologically, both tumors were composed of smooth-muscle cells, fat cells, and blood vessels, and contained foci of extramedullary hematopoiesis. Although the smooth-muscle cell component was predominant and both tumors exhibited some pleomorphism, no mitosis was found. These histologic findings are consistent with the diagnosis of AML.
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PMID:Multiple angiomyolipoma of the liver. 779 37

Primary angiomyolipoma of the liver is a rare entity with fewer than 40 cases described in the English literature. Primary hepatic tumors diagnosed during pregnancy are also rare with adenomas, hemangiomas, and hepatocellular carcinoma having been described. This article reports a patient who was diagnosed with a large liver mass at 16 weeks gestation. The patient successfully completed her pregnancy and ultimately underwent resection of a giant hepatic angiomyolipoma. The literature on angiomyolipoma as well as liver tumors during pregnancy is reviewed.
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PMID:Angiomyolipoma of the liver presenting in pregnancy. 797 73

Angiomyolipoma, a rare benign liver tumor, was observed in a 50-year-old woman examined with US, CT, MR imaging and angiography. Dynamic studies using CT and MR imaging were valuable in differentiating the disease from hepatocellular carcinoma with fat deposits.
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PMID:Angiomyolipoma of the liver. Ultrasound, CT, MR imaging and angiography. 831 4

Two cases of rare hepatic angiomyolipoma are reported. Both represented with slight abdominal discomfort. The first patient complained of abdominal fullness, and had a normal physical examination and laboratory data. The second came with epigastralgia. Tenderness over right upper quadrant was noted and positive hepatitis B antigen was found. Ultrasound demonstrated hyperechoic hepatic lesion in both. Although diagnosis of hepatic angiomyolipoma was suspected by the radiological findings of ultrasound, CT, MRI, and angiography, it was confirmed by the histological presence of three mesenchymal components: abundant vessels, mature fat cells and smooth muscle cells. For fear of the coexistence of hepatocellular carcinoma, especially given the high prevalence area of Taiwan, surgical intervention was recommended if liver function permitted. Successful treatment was achieved by hepatic resection in both cases.
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PMID:Hepatic angiomyolipoma: a report of two cases. 882 41

Hepatic angiomyolipoma is a rare entity. In this report, we describe the unusual MR findings of an angiomyolipoma with minimal fat content with histopathology correlation. This tumor had signal intensity features on various MR sequences including intense heterogeneous enhancement on immediate postgadolinium spoiled gradient echo images that resembled the appearance of a well-differentiated primary hepatocellular carcinoma. Angiomyolipoma with minimal fat content should be considered in the differential diagnosis of tumors with early diffuse heterogeneous enhancement on contrast enhanced images.
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PMID:Hepatic angiomyolipoma with minimal fat content: MR demonstration. 889 74

Although some mesenchymal lesions include readily diagnosable entities, some patients have difficult presentations and unusual radiographic results. This review of mesenchymal tumors covers hemangioma, infantile hemangioendothelioma, angiomyolipoma, angiosarcoma, epitheloid hemangioendothelioma, fibroma, malignant fibrous histiocytoma, inflammatory pseudotumor, mesenchymal hamartoma, embryonal sarcoma, and sarcomatoid hepatocellular carcinoma.
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PMID:Mesenchymal tumors of the liver. Diagnostic problems for the surgical pathologist. 942 Aug 96


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