Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019204 (hepatocellular carcinoma)
 71,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors have studied in a comparative way the kinetics of incorporation of labelled heterologous DNA in tumor and nontumor cells of an identical histological type, obtained from non-irradiated and irradiated with 800 rad rats. It has been shown that the process of incorporation of heterologous high-polymer DNA in cells is somewhat undulatory, and its temporal characteristics and level -- tissue-specific. Difference between tumor cells and their normal prototype show a quantitative character, conditioned by a large surface area. 30 minutes following the irradiation qualitative changes opposite for both kinds of cells were observed in the kinetics of incorporation: an acceleration for lymphoyctes and retardation for Pliss lymphosarcoma and Zajdela hepatoma cells.
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PMID:[Transport of heterologous DNA in normal and tumor cells and its modification by radiation]. 18 51

The authors report the results of separate determination of the concentration of free adenine nucleotides (ATP, ADP, AMP) in tumors, intact animals liver, and tumor-bearing animals liver. In Zajdela ascites hepatoma, ascites tumor NKly and solid lymphosarcoma, solid hepatomas 46 and 22 A the amount of ATP and ADP was found to be markedly reduced compared with their content in the liver. The ratio ATP/ADP is increased in ascites cells of tumor NKly, Zaidela hepatoma and lymphosarcoma and is decreased in solid hepatoma 46 and 22 A. Cell energy potential, calculated on the basis of ATP ratio to a sum of adenine-nucleotides, is also increased in ascites cells of tumor NKly, Zaidela hepatoma and is diminished or remains unchanged in hepatoma 46 or 22A. Cell energy charge is increased in tumor NKly, Zajdela hepatoma, lymphosarcoma and is decreased in solid hepatoma 46 and 22A.
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PMID:[Content of the components of the adenylic acid system in solid and ascitic tumors in the liver of experimental animals]. 19 12

Authors give results about 60 laparoscopies in negro immigrants. If one excepts isolated cases of liver cirrhosis, hepatoma, staphylococcic liver abscess, lymphosarcoma or schistosomiasis of the peritoneum and twelve normal laparoscopies, the most frequent diagnosis in this peculiar group is peritoneal and/or liver tuberculosis (21 cases). Endoscopic aspects of hepato-splenic schistosomiasis are summarized. Interest of liver and/or peritoneal biopsies is underlined. Problem of liver granulomatosis may be ambiguous between schistosomiasis and tuberculosis.
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PMID:[Laparoscopy in black African immigrants. Apropos of 60 cases]. 21 15

Thirty-two children with solid tumors (lymphangioma, fibrosarcoma, hepatocarcinoma, osteogenic sarcoma, rhabdomyosarcoma, lymphosarcoma, mesenchymoma, hepatoma, Ewing's sarcoma, reticulum cell sarcoma, neuroblastoma, Hodgkin's disease, and brain tumors) were studied for alterations in coagulation by means of platelet counts, platelet aggregation, thrombelastogram, procoagulant and antigenic factor VIII, fibrin split products, and antithrombin III level. Results indicated hypercoagulability as shown by abnormally short thrombelastograms and elevated factor VIII levels and platelet counts in approximately one-half of the group. With the exception of increased fibrin split products in a third of the patients, little laboratory or clinical evidence for disseminated intravascular coagulation was seen. Hypercoagulability, as noted in adult carcinoma patients, can also occur in childhood sarcoma patients.
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PMID:Hypercoagulability in childhood cancer. 120 73

Serum alpha-fetoprotein (AFP) concentration was detected by use of 2 commercially available kits containing antibodies to human AFP--a radioimmunoassay and an enzymetric test. Using neonatal canine serum (a source high in AFP), it was determined that reagents from both kits were able to bind to canine AFP, but a significant difference was detected in AFP concentration. The enzymetric test was superior in detecting canine AFP. Sera from dogs were classified into 6 groups: from dogs with primary hepatic tumors only (group 1); from dogs with primary hepatic tumors and other tumors (group 2); from dogs with normal liver but with other types of neoplasia (group 3); from dogs with nonneoplastic hepatic disease and tumors originating in other organs (group 4); from dogs with nonneoplastic hepatic disease only (group 5); and from clinically normal dogs (group 6). Serum biochemical determinations (alkaline phosphatase, alanine transaminase, albumin, total protein, total bilirubin, and serum bile acids) and values from the 2 AFP assays were obtained for all dogs. Serum AFP concentration detected by the enzymetric test was significantly higher in dogs with hepatocellular carcinoma and cholangiocarcinoma. Values greater than 250 ng/ml were detected in 5 of 9 dogs with cholangiocarcinoma and in 3 of 4 dogs with hepatocellular carcinoma. High serum AFP concentration also was indicative of liver involvement in 2 of 3 dogs with primary hepatic lymphosarcoma; 2 dogs had values greater than 225 ng/ml. Serum AFP concentration in dogs with other types of hepatic tumors was less than 250 ng/ml, and serum AFP concentration could not be correlated with such tumors.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Detection of serum alpha-fetoprotein in dogs with hepatic tumors. 172 Jan 15

Forty-eight cases of dogs with primary and metastatic hepatic neoplasia were reviewed to determine if a predictable relationship between sonographic appearance and neoplastic cell type could be found. A focal mass was almost always a hepatocellular carcinoma (14 of 15) and 71% of these were hyperechoic. Focal or multifocal hyperechoic masses were most likely to be carcinomas (14 of 15). Focal or multifocal mixed neoplasms were most likely to be carcinomas (6 of 7). Two distinct patterns of lymphosarcoma were found: diffuse, mildly hyperechoic (6/11) and multifocal, hypoechoic (5/11). No neoplastic cell-type predictions could be made for focal or multifocal hypoechoic lesions. Diffuse fine or coarse patterns with minimal architectural distortions could be mistaken for normal or degenerative processes. However, in the presence of increased serum liver enzyme values, these subtle sonographic changes would warrant a liver biopsy to differentiate neoplastic infiltrate from non-neoplastic infiltrative and degenerative processes.
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PMID:Ultrasonographic appearance of primary and metastatic canine hepatic tumors. A review of 48 cases. 268 92

A study of the condition and function of a multienzymatic monoxygenase system in liver microsomes of rats bearing experimental Pliss' lymphosarcoma and Zajdela's ascites hepatoma showed synthesis and function of the key enzymes of the hydroxylating microsomes of the liver being inhibited and, consequently, drug metabolism slowed down.
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PMID:[Metabolic characteristics of xenobiotics in the liver of tumor-bearing rats]. 342 9

It is established that rat immunization with tularemia living vaccine inhibits Pliss lymphosarcoma growth and increases the life duration to tumour bearing animals. In tests with Zajdela ascitic hepatoma in 1/3 of the immunized animals ascites were not formed and the rats lived 150 days before they were killed.
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PMID:[Enhanced antitumor resistance in rats immunized with a tularemia vaccine]. 375 29

The paper deals with a study of the effect of a single challenge with living tularemia vaccine on the growth of such transplantable tumors as Zajdela's hepatoma, Pliss' lymphosarcoma, Walker's carcinosarcoma, Schwetz' erythromyelosis and sarcoma 45 in Wistar rats. Immunization was followed by a significant (37.2-86%) inhibition of the rate of growth of the said tumors. Ascites was detected in half the vaccinated animals of Zajdela's hepatoma series, this being matched by 100% in controls.
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PMID:[Effect of immunization with live tularemia vaccine on the growth of various tumor strains in rats]. 407 86

Four treatment groups (80 male Sprague-Dawley rats/group) were used in a 2 X 2 factorial design: inhalation of 600 ppm vinyl chloride (VC) 4 hr/day, 5 days/week for 1 year; VC and ingestion of 5% ethanol in water (v/v); filtered air and ethanol; filtered air. Ingestion of ethanol was begun 4 weeks prior to inhalation of VC and continued for life or termination of the study at two and one-half years from the first VC exposure. In this model system, ethanol potentiated the carcinogenic response to VC in the liver and produced an excess of neoplasms in animals receiving ethanol alone. Inhalation of VC induced angiosarcoma of the liver in 23% of the exposed animals; ethanol in addition to VC inhalation increased the incidence to 50%. Concomitant administration of VC and ethanol also produced an excess of hepatocellular carcinoma and lymphosarcoma. Ethanol with or without VC had a strong tumorigenic effect on the endocrine system. These results indicate that ethanol is a cocarcinogen in relation to the carcinogen VC.
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PMID:Effect of ethanol on vinyl chloride carcinogenesis. 627 14


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