Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019204 (hepatocellular carcinoma)
 71,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In an attempt to substantiate the claim that pityriasis rotunda may be a useful cutaneous marker of hepatocellular carcinoma in South African Blacks, the prevalence of the rash in 63 unselected South African Blacks with this tumour was compared to that in 63 matched patients with active tuberculosis, 63 with other malignant tumours, and 63 with various forms of chronic benign hepatic disease. The prevalence of pityriasis rotunda in hepatocellular carcinoma was 15.9%, which was appreciably greater (P = 0.0005) than the overall prevalence of the rash (2.6%) in the controls. The prevalence was 4.8% for tuberculosis (P = 0.038), 0% for other malignant diseases (P = 0.0007), and 3.2% for chronic benign hepatic disease (P = 0.015). We conclude that the presence of pityriasis rotunda is a useful pointer to the diagnosis of hepatocellular carcinoma in South African Blacks.
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PMID:Pityriasis rotunda as a cutaneous marker of hepatocellular carcinoma: a comparison with its prevalence in other diseases. 254 37

Although paraneoplastic phenomena occur frequently in patients with hepatocellular carcinoma, cutaneous changes have rarely been reported. During the past two years, ten South African blacks with hepatocellular carcinoma and pityriasis rotunda have been seen in a single hospital. The rash affected the trunk, especially the lower back and buttocks. The lesions ranged in size from 1.5 to 25 cm and were always multiple. They had a characteristic circular or arcuate configuration with scaling and varying degrees of hyperpigmentation. Pityriasis rotunda may prove to be a useful cutaneous marker of hepatocellular carcinoma in South African blacks.
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PMID:Pityriasis rotunda. A cutaneous marker of hepatocellular carcinoma in South African blacks. 301 46

Pityriasis rotunda is described as persistent, large, sharply defined circular patches of dry ichthyosiform scaling with no inflammatory changes. Pityriasis rotunda may be associated with systemic diseases (eg. hepatocellular carcinoma). We report a case of pityriasis rotunda in a 19-year-old, otherwise healthy male. The condition started one year prior to his referral. Lesions were distributed over the trunk and upper extremities. Histopathological examination revealed hyperkeratosis, absent granular layer, pigmented basal layer, pigmentary incontinence and perivascular lymphocytic infiltrate. PAS staining for fungi was negative. Treatment of pityriasis rotunda in this case was challenging. When there's an underlying disease, successful treatment of the original disease leads to clearance of pityriasis rotunda lesions.
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PMID:Photoletter to the editor: Pityriasis Rotunda. 2309 87