Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019204 (hepatocellular carcinoma)
 71,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the present study, we found that various concentrations of methylene blue (38, 3.8, 0.38, 0.038, 0.0038 mumol/L) significantly inhibited DNA synthesis in ascites hepatoma (AH) cells. The inhibition increased with the concentration of methylene blue as well as with irradiation time. Photosensitization of methylene blue was not due to 1O2, OH., or O2.-, but was closely related to H2O2. The mechanism of inhibition of DNA synthesis may be attributed to the damage of DNA replication template.
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PMID:[Mechanism of the photosensitive effects of methylene blue in the inhibition of DNA synthesis in cancer cells]. 132 42

Morin (0.012, 0.12, 1.2, 12.0 micrograms.ml-1) significantly inhibited the DNA synthesis of ascitic hepatoma (AH) cells. The inhibition of DNA synthesis and cell mortality was dependent on its concentrations as well as the illumination time. Photosensitization of morin was not due to 1O2 and O2-, but closely related to OH. and H2O2. The mechanism of the inhibition may be attributed to the damage of DNA replication template.
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PMID:[Inhibition of photosensitization of morin on DNA synthesis of ascites hepatoma cells]. 159 39

Photosensitization induced by tetrabromofluorescein (eosin, 3.8 mumol/L) in ascites hepatoma cells or in normal kidney cells of mice was found to be significant. The cytocidal activity increased in proportion to the concentration of fluorescein as well as with irradiation time. ESR signals were not detected using a trapping agent, 2,2,6,6-tetramethyltetrahydroxy-piperidine (TMHP) which functions as a singlet oxygen probe. No effect on photosensitization by superoxide dismutase (SOD), NaN3, histidine, mannitol or beta-carotene were observed. However, catalase did decrease photosensitization. These results indicate that cytocidal activity is not related to 1O2, O2-. or OH., but is related to H2O2. The cytocidal activity of tetrabromofluorescein in ascites hepatoma cells is stronger than that in normal kidney cells.
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PMID:[Mechanism of active oxygen in cytocidal activity of tetrabromofluorescein]. 248 20

The impact of intensity of glycolysis and oxidative phosphorylation on death of photosensitized murine hepatoma MH22 cells in vitro has been investigated. Cells photosensitized with meso-tetra(4-sulfonatophenyl)-porphine localized to lysosomes died mostly by necrosis, and the mode of cell death did not depend on the energy metabolism. Photosensitization with 5-aminolevulinic acid-stimulated endogenous porphyrins localized mainly in mitochondria or 5,10,15,20-tetrakis(m-hydroxyphenyl)-chlorine localized to cell membranes, including mitochondria, led to cell death mostly by apoptosis. In this case, the mode of cell death depended on the medium: under conditions unfavorable to glycolysis the ratio apoptosis/necrosis decreased significantly.
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PMID:Correlation of death modes of photosensitized cells with intracellular ATP concentration. 1455 May 67