Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019204 (hepatocellular carcinoma)
 71,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eleven children, ranging in age from three months to fifteen years, with primary liver tumors were examined by large volume direct magnification arteriography (2.5--3 ml of contrast material per 1 kg body weight for a single selective study). The following tumors were found: hepatoblastoma (1), hepatocellular carcinoma of the adult type, hepatoma (3), infantile hemangioendothelioma (4), hemangiosarcoma (1), focal nodular hyperplasia (1) and cystic mesenchymal hamartoma (1). Some of the tumors have a quite typical angiographic appearance as infantile hemangioendothelioma, hemangiosarcoma, cystic mesenchymal hamartoma. The other highly vascular neoplasms show unspecific signs of vascular malignant tumors; subtile angiographic signs may, however, be present and help in the differential diagnosis.
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PMID:Primary liver tumors in the pediatric age group: an angiographic challenge. 22 Jan 63

We report a histological analysis of the areas of high density in the postequilibrium and delayed phase CT in 43 focal hepatic lesions. The cases consisted of 16 cholangiocellular carcinomas, 9 hepatocellular carcinomas (including a sclerosing type of hepatocellular carcinoma and a combined hepatocellular-cholangiocellular carcinoma), 13 metastases, 2 granulomas, an inflammatory pseudotumor, a malignant lymphoma, and an epithelioid hemangioendothelioma. Computed tomography was performed after hepatic angiography using 40-50 g iodine and arteriographic CT using 35 g iodine. The areas of delayed enhancement corresponded histologically to fibrotic tissues, from inflammatory change to extensive fibrosis.
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PMID:Delayed enhancement of fibrotic areas in hepatic masses: CT-pathologic correlation. 131 98

The different types of primary hepatic tumors are examined, focusing on their macroscopic and histologic features. A large variety of neoplasms can be observed, derived from the different components of the liver. Benign (adenoma, focal nodular hyperplasia) or malignant (hepatocellular carcinoma) epithelial tumors of hepatocellular origin are very common. Hemangioma is the most common mesenchymatous-derived tumor. However, the frequency of each type of tumor varies considerably in the different age and sex groups. Some special entities recently reported, such as epithelioid hemangioendothelioma or fibrolamellar carcinoma are detailed.
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PMID:[Different varieties and anatomopathological description of primary tumors of the liver]. 145 33

One hundred and fifteen patients underwent orthotopic liver transplantation (OLT) for primary liver malignancy. Overall survivals of these patients were significantly lower than those of patients with non-malignant diseases (5-year survival rates 37% and 65%, respectively). Hepatocellular carcinoma (HCC) was the most common malignancy among our patients (n = 80). Fibrolamellar HCC (n = 9) was associated with better survival than non-fibrolamellar HCC (N = 71) among the lesions greater than or equal to 5 cm in diameter. More frequent recurrence was noted in patients with large tumors (greater than or equal to 5 cm), multiple tumors, and gross vascular involvement. A significant lower survival rate was observed in patients with bile duct cancer (n = 19) than in those with HCC or epithelioid hemangioendothelioma (n = 8). Careful patient selection and effective adjuvant anti-cancer therapy are needed to improve the results of OLT for primary liver malignancy.
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PMID:Liver transplantation in the treatment of primary liver cancer. 216 Apr 21

Recent developments in the pathologic assessment of several benign hepatic processes are reviewed, with particular emphasis on distinguishing these processes from malignant lesions. Liver cell dysplasia remains a controversial lesion, with mounting evidence to support its preneoplastic nature. Adenomatous hyperplastic nodules are large regenerative nodules in cirrhotic livers, and may also have malignant potential. Distinguishing these nodules from hepatocellular carcinoma by histology may become increasingly important, with the advent of more sensitive imaging techniques. Differentiating features of noncancerous biliary epithelium versus well-differentiated cholangiocarcinoma, sclerosing hemangioma versus epithelioid hemangioendothelioma, and angiomyelolipoma versus the clear cell variant of hepatocellular carcinoma are also presented and discussed.
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PMID:Pathologic assessment of liver cell dysplasia and benign liver tumors: differentiation from malignant tumors. 219 58

MR features of 153 proved primary liver tumors (95 malignant, 58 benign) in 55 patients with hepatocellular carcinoma (21), cholangiocarcinoma (seven), carcinosarcoma (one), hepatoblastoma (one), hemangioma (16), hepatic adenoma (four), focal nodular hyperplasia (three), leiomyoma (one), and hemangioendothelioma (one) were studied retrospectively to determine which techniques are most reliable for lesion detection and which criteria are most useful for differential diagnosis. MR data were correlated with histologic features such as fatty degeneration, fibrosis, and peritumoral edema. Unlike metastatic cancer, hepatocellular carcinoma was best detected (p less than .01) with T2-weighted pulse sequences. The mean tumor-liver T2 difference was 34.4%, while the mean T1 difference was only 21.8%. A tissue-specific diagnosis of hepatocellular carcinoma was possible in 14 of 21 patients by identification of fatty degeneration of the tumor (eight of 17), tumor capsule (five of 21), and/or vascular invasion (six of 21). MR features of peritumoral edema, present in six of 21 patients with hepatocellular carcinoma and in seven of 25 patients with metastases, were exclusively associated with malignant tumors. The large variation in tissue characteristics (relaxation times and proton density) seen in primary liver tumors necessitates the use of multiple pulse sequences to maximize lesion detection. However, the combined use of T1- and T2-weighted spin-echo and T2-weighted phase-contrast images had the advantage of distinguishing benign from malignant primary liver tumors in 48 of 55 patients in this series.
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PMID:Primary liver tumors: diagnosis by MR imaging. 253 70

Hepatoblastoma is the most common primary malignant hepatic neoplasm in children and must be differentiated from other hepatic tumors such as hepatocellular carcinoma, metastatic neuroblastoma, hemangioendothelioma, and mesenchymal hamartoma. A case report of hepatoblastoma with its attendant radiologic findings is presented. Because the prognosis is dependent on whether the tumor is surgically resectable, the accurate radiologic evaluation of patients with hepatoblastoma is critical. The roles of plain film radiography, ultrasound, computed tomography, and angiography in the evaluation of pediatric hepatic neoplasms are discussed.
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PMID:Hepatoblastoma: case report and literature review. 254 39

Computed tomography (CT) was performed in three children with hepatoblastoma, hepatocellular carcinoma, or hemangioendotheliomatosis. In each case the tumor was identified as a mass with a lower attenuation value than surrounding normal liver tissue. However, the hemangioendothelioma became almost undetectable after intravenous injection of contrast agent. Identification of the intersegmental fissure of the left lobe allowed correct prediction of the segmental location of the solitary lesion (hepatoblastoma and hepatocellular carcinoma) in the two patients who underwent subsequent partial hepatic resection.
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PMID:Computed tomography of primary liver tumors in children. 626 Dec 91

Presentation is made of 27 cases of liver neoplasms in infancy and childhood that were admitted to the Pediatric Hospital of the National Medical Center of the IMSS, through a period of 15 years. Sixteen cases were diagnosed as hepatoblastoma, 2 as hepatocellular carcinoma, 4 as mesenchymal hamartoma, 2 as hemangioendothelioma of infantile type, 2 were embryonal rhabdomyosarcoma of the intrahepatic bile-ducts and one case of multiple bile-ducts hamartoma. The hepatoblastoma and the mesenchymal hamartoma are neoplasms that appear more frequently before the age of 2 years; the hepatocellular carcinoma, after 5 years of age and the infantile hemangioendothelioma generally appears before 6 months old. In all, benign and malignant cases, the clinical manifestations were non specific and did not help to establish the diagnoses. The mesenchymal hamartomas were characterized by the fast growth that led to think in neoplasms of malignant nature. The selective treatment is lobectomy with a better prognosis if the neoplasm is located in the left lobe. The right lobe was the most frequently affected by the benign tumors, as well as by the malignant, and the lung was the organ wherein metastases more often were found.
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PMID:[Liver neoplasms in children]. 627 66

The potential carcinogenicity of captafol in B6C3F1 mice was examined. Captafol was given at levels of 0 (control), 0.075, 0.15 or 0.3% in the diet to a total of 203 males and 203 females for 96 weeks, after which time the animals were returned to basal diet for a further 8 weeks. Mice surviving 42 weeks or longer were included in the effective numbers. Males and females given 0.3% captafol showed increased cumulative mortalities in the final quarter period of the experiment. Significant increases in the development of neoplastic lesions were found in the heart, spleen, forestomach, small intestine and liver of mice of both sexes treated with captafol. Tumors induced by captafol were, histologically, hemangioendothelioma in the heart, hemangioma or hemangioendothelioma in the spleen, papilloma and squamous cell carcinoma in the forestomach, adenoma and adenocarcinoma in the small intestine, and hyperplastic nodule and hepatocellular carcinoma in the liver. These results demonstrate a broad-spectrum carcinogenicity of captafol in B6C3F1 mice.
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PMID:Carcinogenicity of captafol in B6C3F1 mice. 651 Jun 34


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