Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019204 (hepatocellular carcinoma)
 71,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This report presents a review of tumors, except those of pituitary, that have been reported to occur in women taking combined oral contraceptive preparations. Pathologic features, both gross and microscopic, and differential diagnosis are emphasized. Particular attention is given to tumors of the liver: focal nodular hyperplasia (hepatic hamartoma) and liver cell adenoma (benign hepatoma). The characteristic features of these usually distinctive lesions are illustrated, and an attempt is made to evaluate the significance of each with respect to oral contraceptives. Tumorigenic aspects relating to the uterus and the breast are briefly discussed.
 ...
PMID:Tumorigenic aspects. 3 11

The possible association between oral contraceptives and benign liver tumors has recently been reported. To date the majority of cases have been diagnosed as benign hepatomas (liver cell adenomas). We have had the opportunity to study 13 such cases. Eight have been examples of focal nodular hyperplasia of the liver; however, in addition, there were examples of hepatocellular carcinoma, liver cell adenoma, and possible liver cell hamartoma; all were in women on "the pill." Gynecologists are alerted to the fact that many of the patients present with symptoms of acute abdomen, syncope or shock, and intrahepatic or intraperitoneal bleeding. Prompt diagnosis and treatment may be lifesaving.
 ...
PMID:Liver tumors in women on contraceptive steroids. 16 23

Within the last several years, previously rare liver tumors have been seen in young women using oral contraceptive steroids. The Registry for Liver Tumors Associated with Oral Contraceptives at the University of California, Irvine, has clearly identified 27 cases. The recent literature contains 44 case reports. Common to these 71 cases has been a histopathologic diagnosis of focal nodular hyperplasia, adenoma, hamartoma, and hepatoma. Significant statistical etiologic factors include prolonged uninterrupted usage of oral contraceptive steroids. Eight deaths and liver rupture in 18 patients attest to the seriousness of this new potentially lethal adverse phenomenon.
 ...
PMID:Etiologic factors in the pathogenesis of liver tumors associated with oral contraceptives. 18 39

Eleven children, ranging in age from three months to fifteen years, with primary liver tumors were examined by large volume direct magnification arteriography (2.5--3 ml of contrast material per 1 kg body weight for a single selective study). The following tumors were found: hepatoblastoma (1), hepatocellular carcinoma of the adult type, hepatoma (3), infantile hemangioendothelioma (4), hemangiosarcoma (1), focal nodular hyperplasia (1) and cystic mesenchymal hamartoma (1). Some of the tumors have a quite typical angiographic appearance as infantile hemangioendothelioma, hemangiosarcoma, cystic mesenchymal hamartoma. The other highly vascular neoplasms show unspecific signs of vascular malignant tumors; subtile angiographic signs may, however, be present and help in the differential diagnosis.
 ...
PMID:Primary liver tumors in the pediatric age group: an angiographic challenge. 22 Jan 63

The authors report some unusual pediatric conditions where grey scale ultrasound was the most useful diagnostic tool. Cases of pericardial cyst, polycystic kidney disease of the adult type, hepatic hamartoma and hepatocarcinoma, gallstones, renal pseudo tumors, calcified inferior vena caval thrombus, acute pancreatitis, multicystic kidney and retroperitoneal lymphangioma are briefly described and compared to the literature. In a patient presenting with hereditary tyrosinemia, ultrasound not only disclosed evidence of hepatocarcinoma but was shown to be the procedure of choice for following the course of the disease.
 ...
PMID:Rare pediatric conditions: contribution of grey-scale ultrasonography. 51 81

The presence of hepatitis B virus (HBV) has been evaluated in liver specimens from 11 children with primary liver tumors and negative results of serologic testing for HBV markers. HBV-DNA sequences were detected by the polymerase chain reaction procedure, using different sets of oligonucleotide primers from highly conserved regions of HBV genome. Two of three children with histologic diagnosis of hepatocellular carcinoma were positive for HBV-DNA in the liver, whereas the remaining children, including six patients with hepatoblastoma, one patient with hemangioma, and one patient with hamartoma, were negative. These findings support the hypothesis of a primary role of HBV in the development of hepatocellular carcinoma in children from nonendemic areas and without overt HBV infection.
 ...
PMID:Latent hepatitis B virus infection in childhood hepatocellular carcinoma. Analysis by polymerase chain reaction. 131 10

Hepatoblastoma is the most common primary malignant hepatic neoplasm in children and must be differentiated from other hepatic tumors such as hepatocellular carcinoma, metastatic neuroblastoma, hemangioendothelioma, and mesenchymal hamartoma. A case report of hepatoblastoma with its attendant radiologic findings is presented. Because the prognosis is dependent on whether the tumor is surgically resectable, the accurate radiologic evaluation of patients with hepatoblastoma is critical. The roles of plain film radiography, ultrasound, computed tomography, and angiography in the evaluation of pediatric hepatic neoplasms are discussed.
 ...
PMID:Hepatoblastoma: case report and literature review. 254 39

Since 1977, eight children have had major liver resections with the aid of normovolemic hemodilution anesthesia. Five children were 7 months of age or less; the other three were 3 1/2, 8, and 12 years old. This includes three operations for hepatoblastoma, three for hepatoma, and two for mesenchymal hamartoma. There were three right lobectomies, two trisegmentectomies, two extended left lobectomies, and one standard left lobectomy. With the use of this method, operative blood loss has been greatly reduced and operating technique significantly improved. After abdominal exploration and initial liver mobilization, whole blood is removed from the patient and simultaneously replaced with three times the volume of Ringer's lactate solution to maintain adequate intravascular volume. After the major blood loss has ceased, the patient is reinfused with his own blood and a simultaneous diuresis is induced with LASIX to remove the previously administered crystalloid solution. Metabolic demand is reduced by allowing the patient's temperature to drift down to 32 degrees C. Blood loss is further reduced by a Halothane-induced hypotension to a mean arterial pressure of 40 to 50 torr. The diluted blood lost during surgery has a low red blood cell volume per cc; therefore, each cc of blood lost depletes the total red cell volume by a lesser amount. This results in a nearly bloodless operative field which facilitates the ease, speed, and safety of the dissection. Use of this technique can avoid the need for massive intra-operative transfusions and the threat of cardiac arrest due to extensive blood loss during major liver resection in children.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:The advantages of hemodilution anesthesia for major liver resection in children. 609 59

Presentation is made of 27 cases of liver neoplasms in infancy and childhood that were admitted to the Pediatric Hospital of the National Medical Center of the IMSS, through a period of 15 years. Sixteen cases were diagnosed as hepatoblastoma, 2 as hepatocellular carcinoma, 4 as mesenchymal hamartoma, 2 as hemangioendothelioma of infantile type, 2 were embryonal rhabdomyosarcoma of the intrahepatic bile-ducts and one case of multiple bile-ducts hamartoma. The hepatoblastoma and the mesenchymal hamartoma are neoplasms that appear more frequently before the age of 2 years; the hepatocellular carcinoma, after 5 years of age and the infantile hemangioendothelioma generally appears before 6 months old. In all, benign and malignant cases, the clinical manifestations were non specific and did not help to establish the diagnoses. The mesenchymal hamartomas were characterized by the fast growth that led to think in neoplasms of malignant nature. The selective treatment is lobectomy with a better prognosis if the neoplasm is located in the left lobe. The right lobe was the most frequently affected by the benign tumors, as well as by the malignant, and the lung was the organ wherein metastases more often were found.
 ...
PMID:[Liver neoplasms in children]. 627 66

Expression of cytokeratins no. 7 and no. 19, typical of the mature biliary tract and of embryonic and fetal hepatocytes, has been evaluated in primary liver tumors from 12 children. Of 7 children with hepatoblastoma, 6 were strongly reactive for cytokeratin no. 19 and only 4 were weakly positive for cytokeratin no. 7. In contrast, the remaining tumors, including 2 hepatocarcinomas, 1 sarcoma, 1 hamartoma and 1 hemangioma were positive for cytokeratin no. 7, while cytokeratin 19 was present in 1 hepatocarcinoma and in the hamartoma. All these tumors, as well as 1 hepatoblastoma and the sarcoma, were also reactive for cytokeratin no. 8, typical of hepatic cells.
 ...
PMID:Cytokeratins patterns in childhood primary liver tumors. 751 Jan 49


1 2 3 4 Next >>