Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Acetyl-CoA synthetase 2
(
ACSS2
) generates acetyl-CoA from acetate is important for histone acetylation and gene expression.
ACSS2
fulfills distinct functions depending on its cellular location in tumor cells. The role and cellular localization of
ACSS2
in
hepatocellular carcinoma
(
HCC
) remains to be studied. Herein, we identified that the alternative transcription start site selection of
ACSS2
was significantly different between
HCC
and corresponding adjacent tissues. Alternative transcription start site selection produced two different
ACSS2
transcripts,
ACSS2
-S1 and
ACSS2
-S2. The two isoforms of
ACSS2
had different subcellular localization and different functions. Overexpression of
ACSS2
-S2 promoted cell proliferation and invasion, but
ACSS2
-S1 did not. The
ACSS2
-S1 was mainly present in cytoplasm, and
ACSS2
-S2 was distributed in both nucleus and cytoplasm. Finally, we demonstrated that alternative transcription start site selection of
ACSS2
correlates ribosome biogenesis in
HCC
. Our findings reveal an oncogenic role of
ACSS2
-S2 in
HCC
progression via increase of ribosome biogenesis, and suggest
ACSS2
-S2 might be a potential therapeutic target against the
HCC
.
...
PMID:Alternative transcription start site selection in ACSS2 controls its nuclear localization and promotes ribosome biosynthesis in hepatocellular carcinoma. 3107 6
