Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The Melanoma Antigen Gene (MAGE) family is a large, highly conserved group of proteins which was reported to participate in the progression of multiple cancers in humans. However, the function of distinct MAGE genes in
hepatocellular carcinoma
(
HCC
) is largely unclear. In this study, we comprehensively evaluated the expression, clinical significance, genetic alteration, interaction network and functional enrichment of MAGEs in
HCC
. Our research showed that many MAGE genes were dysregulated in
HCC
. Among them, MAGEA1, MAGEC2, MAGED1, MAGED2,
MAGEF1
and MAGEL2 were significantly associated with clinical stage and differentiation of
HCC
. MAGED1, MAGED2, MAGEA6, MAGEA12, MAGEA10, MAGEB4, MAGEL2 and MAGEC3 significantly correlated with
HCC
prognosis. Further functional enrichment analysis suggested the dysregulated MAGEs may play important roles in signal transduction. These results indicate that multiple dysregulated MAGEs might play important roles in the development of
HCC
and can be exploited as useful biomarkers for diagnosis and treatment in
HCC
.
...
PMID:A comprehensive analysis of the MAGE family as prognostic and diagnostic markers for hepatocellular carcinoma. 3294 82
