Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019163 (
hepatitis B
)
38,309
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hepatocellular carcinoma (HCC) is an aggressive malignant tumor and the third leading cause of cancer-related mortality worldwide.
Transmembrane channel-like protein 8
(
TMC8
) is reported to play a major role in several aspects of human pathophysiology, such as ion channel permeability, human papillomavirus infection and skin cancer; however, its role in HCC has not been fully elucidated. The aim of the present study was to investigate the expression levels of
TMC8
in 146 pairs of liver cancer samples and adjacent non-tumorous samples using immunohistochemistry. Reverse transcription-quantitative polymerase chain reaction analysis was used to confirm the results. The association between
TMC8
expression and clinicopathological characteristics, including overall survival, was analyzed. The results indicated that the expression of
TMC8
was significantly upregulated in HCC tissues and associated with metastasis and
hepatitis B
virus infection. According to the analysis of the overall survival using Cox proportional hazard regression model, higher expression of
TMC8
was associated with a poorer prognosis and the overexpression of
TMC8
was an independent risk factor for HCC. By contrast, HBsAg did not significantly affect the survival of HCC patients. These results suggest that the overexpression of
TMC8
in HCC predicts poor prognosis and may be a potential biomarker for this type of cancer.
...
PMID:Transmembrane channel-like protein 8 as a potential biomarker for poor prognosis of hepatocellular carcinoma. 2878 95
