Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019163 (
hepatitis B
)
38,309
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The aim of this study was to investigate the inhibitory effect of regulation of miR-122-
MAP3K2
signal pathway on the
hepatitis B
cells. We detected the content of
MAP3K2
from patients with HBV blood serum samples and analyzed the correlation between content of
MAP3K2
and copies of HBV-DNA. Wound healing and Transwell assays were used to detect the function of cells from control group (wild type) and observer group (overexpresses miR-122). Secretion levels of HBsAg and
MAP3K2
in the supernatant and level of
MAP3K2
in cells were detected by ELISA and western blot, respectively. The results showed that there was a positive correlation between the copies of HBV-DNA and
MAP3K2
in serum. In the assays involving detection of the number of HBV-DNA copies, the supernatant levels of HBsAg and
MAP3K2
, and the level of
MAP3K2
in the cells, the rate of increase of these indicators significantly slowed as culture time. In conclusion, overexpression of miR-122 could inhibit the migration of hepatoblastoma cells; however, following transfection with miR-122, DNA synthesis and the secretion of HBsAg were inhibited. Overexpression of miR-122 can also downregulate
MAP3K2
. Consequently, we concluded that regulating the miR-122-
MAP3K2
signaling pathway exerts an inhibitory effect in
hepatitis B
cells.
...
PMID:Inhibitory Effect on the Hepatitis B Cells through the Regulation of miR-122-MAP3K2 signal pathway. 3114 Oct 15
