Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019163 (hepatitis B)
 38,309 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hepatitis B virus (HBV) is a small DNA virus belonging to hepadnaviridae. Genomic DNA of HBV has four open reading frames representing the S gene with pre-S1 and pre-S2 regions for envelope protein, the C gene coding for a nucleocapsid protein, the P gene for the putative DNA polymerase, and the X gene encoding a protein with transcriptional transactivating function. The C gene is preceded in phase by the precore region. Recently, this region has been attracting attention because of its role in the synthesis and secretion of HBe Ag. It has been postulated that HBV mutants with precore region defects prevail in persistently infected hosts along with seroconversion to anti-HBe. Recent advances in molecular biology have enabled us to detect minute amounts of HBV DNA by means of polymerase chain reaction (PCR) and to analyze gene function in detail. The advanced techniques and conventional serological assay systems will help in clarifying the pathogenesis of acute and chronic hepatitis B, in preventing and eradicating HBV infection.
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PMID:[Structure of hepatitis B virus and its related serological markers]. 219 5

We demonstrated that cloned hepatitis B virus (HBV) DNA directs the synthesis of a 700-base RNA (HBV 700) by RNA polymerase III in a cell-free transcription system. HBV 700 is the only transcript known to originate from the viral short strand and has been mapped to the region between roughly 1,635 and 954 base pairs on the viral map, between the surface and core antigen coding sequences but overlapping and opposing the putative DNA polymerase and B protein genes. The in vitro initiation sites for the HBV 700 and core antigen RNAs are only 50 bases apart, suggesting that these two genes may be coordinately regulated. Moreover, both of these initiation sites appear to lie within the approximately 300-base double-stranded region (the nick region) between the 5' end of the HBV short strand and the nick in the viral long strand. We found two unusual sequence elements in the nick region that are conserved between the human and woodchuck viruses.
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PMID:Hepatitis B virus encodes an RNA polymerase III transcript. 664 23