Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019163 (
hepatitis B
)
38,309
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Single nucleotide polymorphisms (SNPs) in
ZNF208
may be associated with susceptibility to
Hepatitis B
virus (HBV). In the current study, we analyzed the association between
ZNF208
SNPs and risk of HBV in 242 HBV patients and 300 healthy subjects from the Xi'an area of Chinese Han Population. Of the five SNPs examined, rs2188971 (OR: 1.36, 95% CI: 1.04-1.76,
P
= 0.022), rs8103163 (OR: 1.40, 95% CI: 1.08-1.82,
P
= 0.010) and rs7248488 (OR: 1.38, 95% CI: 1.07-1.79,
P
= 0.014) were correlated with HBV susceptibility based on Chi-square tests. After the
P
-values were adjusted by Bonferroni correction, there only rs8103163 (
P
= 0.050) was slightly with increased HBV risk. Additionally, haplotype A
rs2188972
T
rs2188971
A
rs8103163
A
rs7248488
(OR = 1.42; 95% C I, 1.10-1.85;
P
= 0.008) was found to increase susceptibility of suffering from HBV. These findings suggest that
ZNF208
polymorphisms may contribute to the development of HBV.
...
PMID:Single nucleotide polymorphisms in
ZNF208
are associated with increased risk for HBV in Chinese people. 2934 38
