Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019163 (hepatitis B)
 38,309 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mosquitoes and bed bugs may play a role in the transmission of hepatitis B virus (H.B.V.). We investigated this possibility with the Triatoma Infestans, which is a hematophagous insect widely prevalent in the Argentine Republic. Triatoma Infestans fed with serum or blood contaminated with H.B.V. were studied at 7, 14, and 21 days after contamination. Stool and insect homogenates were positive for HBsAg at each time checked. Considering the domestic habits and hematophagous condition of Triatoma Infestans, we feel that this insect could also play a role in the transmission of H.B.V. through their bites or dejections.
 ...
PMID:[Triatoma infestans as a vector of hepatitis B virus]. 703 39

In a previous study we observed a high prevalence of infection with hepatitis B virus (HBV) among nurses and maids of the elder's home at the Lincoln Town Hospital, Lincoln, province of Buenos Aires, Argentine Republic. The purpose of this study was to know the prevalence of infection with HBV and analyze the serologic pattern found in old people of the home. We studied 38 people of both sexes, older than 60 years, who live at the home. The control group was formed with 91 people with the same characteristics but from the ambulatory clinic. In both groups anti-HBc, anti-HBs and AgHBs were detected by ELISA method. Results were: 3 subjects (7.9%) in the studied group and 6 (6.5%) in the control group presented markers repeatedly. The was no significant statistic difference between both groups (P 0.05). The old people from the elder home of this city, are not in great danger of HBV infection. We relate the high prevalence among nurses and maids with labor and extra labor factors and not with their specific work in this elder home.
 ...
PMID:[Homes for the aged. Are they a high risk population for hepatitis B?]. 829 14

Seven human hepatitis B virus (HBV) genotypes have been described. Genotype F, indigenous to the Americas, is the most diverging group. Our in-depth analysis of the genetic distances of this genotype included ten Argentine samples. Phylogenetic analysis on the small (S) gene of the surface antigen showed four different clusters within genotype F, which were associated with a well-defined geographical origin. Even closely connected sequences sharing a common ancestor had shown some characteristics or markers indicating geographical differentiation. Nucleotide sequences and amino acids translated according to the polymerase open reading frame (P-ORF), rather than S-ORF, yielded a more discriminating analysis.
 ...
PMID:Phylogenetic analysis of the hepatitis B virus (HBV) genotype F including Argentine isolates. 1169 65

Transplantation of hematopoietic progenitor cells (HPC) from bone marrow and mobilized peripheral blood is a standard therapy in malignant and non malignant diseases. The lack of suitable donors is an important limitation. The discovery that umbilical cord blood (CB) contains high numbers of HPC that can be used as an alternative source for allogeneic stem cell transplantation led ITMO to establish BANCEL, the first Argentine and Latinoamerican experience of its kind. The blood remaining in the umbilical cord and in the placenta was requested from women who were in the last quarter of pregnancy. An informed consent together with a medical record focused on family disease was completed. Out of 65 donations, 55 (85%) were collected and 51 (78%) were cryopreserved. Mean collected volume was 110 ml with 68% (75 ml) reduction and mean cryopreservation of 35 ml; ABO and Rh blood group systems were determined, HLA, class I, A and B loci, and class II, DR locus were typed by molecular biology methods using PCR-SSOP. Infectious disease screening was carried out for brucellosis, syphilis, Chagas, hepatitis B and C, HIV I and II, HTLV I and II, toxoplasmosis and cytomegalovirus. Two positive units for hepatitis B (anticore) and two positive units for Chagas were discarded. The quantity of total nucleated cells (TNC), CD34+ cells and the clonogenic capacity were determined twice at the collection and after the procedures of volume reduction previous to cryopreservation. A 5% reduction in both TNC and CD34 cells and a 10% in the colony forming units (CFU) were detected. A good correlation coefficient between TNC and CFU was obtained.
 ...
PMID:[Umbilical cord hematopoietic progenitor cells bank]. 1180 25

A revised analysis on the evolutionary history of hepatitis B virus (HBV) genotype F is herein presented with the incorporation of two new complete genomes from Argentina. The study of the phylogenetic-tree topology, genetic distances, and amino acid mutations confirmed with high reliability the existence of four different genetic clusters of this genotype. Argentine isolates were located in two groups of viruses that showed a great inner homogeneity but, interestingly, divergence between them was in the order of that existing among groups from different locations. Although the origin of these two viral populations is not clear, they do not seem to derive from each other, therefore the existence of at least two founder viral populations in Argentina is a more acceptable explanation.
 ...
PMID:Evolutionary history of Hepatitis B virus genotype F: an in-depth analysis of Argentine isolates. 1291 63

Genotype E hepatitis B virus (HBV) was detected in two Argentine sisters exhibiting an African mitochondrial lineage. One of them (who had been vaccinated against HBV) exhibited anti-HBs cocirculating antibodies without HBsAg escape mutants, while her unvaccinated sister showed a D144A HBsAg escape mutant without anti-HBs antibodies. Both sisters carried an unusual L209V substitution within HBsAg.
 ...
PMID:Detection of hepatitis B virus (HBV) genotype E carried--even in the presence of high titers of anti-HBs antibodies--by an Argentinean patient of African descent who had received vaccination against HBV. 1695 95

Prevalence rates of hepatocellular carcinoma (HCC)-associated hepatitis B virus (HBV) pre-S mutants among most genotypes are still lacking. In this study, viral (sub)genotypes of 70 Argentine nucleotide sequences (33 newly obtained) were determined by phylogenetic analysis, and the presence of such mutants was assessed in the American continent for the first time. Nucleotide substitutions of the pre-S2 start codon were observed in 10% of the HBV/A2 sequences. Ten per cent of the HBV/A2 and 12.5% of the HBV/F1b - but none of HBV/F4 - exhibited a deletion in the pre-S1/pre-S2 region. The contribution of these variants to liver cirrhosis (LC) and/or HCC development among HBV/F and HBV/A isolates deserves further prospective clinical studies.
 ...
PMID:Genotypes B and C hepatocellular carcinoma-associated hepatitis B virus pre-S mutants: their detection among F1b and A2 - but not F4 - isolates from Argentina. 2304 89

In Argentina, current procedures to ensure the safety of the blood supply for transfusion include the serologic detection of specific blood-borne infections. The aim of this study was to evaluate the prevalence and the genetic diversity of hepatitis B virus (HBV) and hepatitis D virus (HDV) in blood donor populations from two distantly located Argentine regions. Data from 56,983 blood donations from the Favaloro Foundation, in the city of Buenos Aires (Central Region), and the Central Blood Bank of Misiones Province (Northeast Region) were analyzed. Samples that were reactive for HBsAg were analyzed for HBV-DNA characterization and HDV serological and molecular analysis. The HBV prevalence was 0.12 % for HBsAg and 1.68 % for anti-HBc antibodies in Buenos Aires, and 0.73 % and 8.55 %, respectively, in Misiones. Seventy-seven HBsAg-reactive samples were analyzed by polymerase chain reaction for HBV-DNA. Subgenotypes A2, B2, C2, F1b and F4 (Buenos Aires) and F1b and D3 (Misiones) were detected. Several mutations within the major hydrophilic region of HBsAg, the reverse transcriptase, the basal core promoter, and the precore/core were detected. HDV genotype 1 was identified in Buenos Aires. This study confirms the circulation of several HBV subgenotypes, as well as known and newly identified variants, and the presence of HDV1 in this population. A thorough investigation has to be carried out to evaluate the clinical importance of some of the documented mutations as well as those detected in the HDV1 case.
 ...
PMID:Hepatitis B virus and hepatitis D virus in blood donors from Argentina: circulation of HBsAg and reverse transcriptase mutants. 2430 25