Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019163 (
hepatitis B
)
38,309
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Herpes virus entry mediator
(
HVEM
) is overexpressed in several malignancies, including hepatocellular carcinoma (HCC). However, to the best of our knowledge, the clinical significance of
HVEM
in
hepatitis B
virus (HBV)-related HCC remains unclear. Thus, the present study aimed to explore the clinical significance of
HVEM
in HBV-related HCC. In the present study,
HVEM
expression was evaluated in HCC cell lines and HCC frozen samples. The prognostic value of
HVEM
was assessed in a cohort of 221 patients with HBV-related HCC, following radical resection. B- and T-lymphocyte attenuator (BTLA) expression in subsets of CD8
+
T cells was determined via flow cytometry analysis. The results demonstrated high
HVEM
expression in HCC cell lines, and in HCC tissues compared with paired non-cancerous liver tissues.
HVEM
expression was demonstrated to be significantly associated with tumor encapsulation and vascular invasion. Furthermore, tumor
HVEM
status was significantly associated with infiltration of regulatory T cells, but not with CD8
+
T cells. Notably, high
HVEM
expression in HCC was determined to be an independent predictor of an unfavorable outcome of patients with HCC following radical resection. Higher BTLA expression (the receptor of
HVEM
) was observed in both HCC-infiltrating CD8
+
effector memory (CCR7
-
CD45RA
-
) and CD45RA
+
effector memory (CCR7
-
CD45RA
+
) T cells in HCC tissues and blood compared with those in paired peritumor tissues or peripheral blood. Taken together, the results of the present study suggest that
HVEM
may serve a critical role in HBV-related HCC, most likely by promoting tumor progression and tumor immune evasion, thus the
HVEM
/BLTA signaling pathway may be a potential target in tumor immunotherapy.
...
PMID:Clinical significance of herpes virus entry mediator expression in hepatitis B virus-related hepatocellular carcinoma. 3277 92
