Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019163 (
hepatitis B
)
38,309
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hepatitis B
virus infection is a worldwide epidemic and is closely associated with the development of hepatocellular carcinoma. Nevertheless, the molecular mechanisms of HBV infection and carcinogenesis remain elusive. Using a hepatocyte model of HBV infection and comparing the gene expression profiling analysis we found that heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 B1 (
HS3ST3B1
,3-OST3-B) is down-regulated in the hepatocytes of chronic HBV infection model.
HS3ST3B1
showed potent inhibitory effect on HBV replication. The inhibitory effect of
HS3ST3B1
overexpression was lost upon gene silencing of
HS3ST3B1
or when a catalytic inactive mutant of
HS3ST3B1
was expressed. Our study revealed the anti-viral activity of
HS3ST3B1
on HBV replication. It is conceivable that possible therapeutic applications of HBV infection could be devised by manipulating
HS3ST3B1
activity.
...
PMID:Heparin sulphate D-glucosaminyl 3-O-sulfotransferase 3B1 plays a role in HBV replication. 2070 11
