Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019163 (hepatitis B)
 38,309 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The cellular and molecular characteristics of SNU human cancer cell lines established in Korean are summarized according to the genetic and epigenetic alterations and functional analysis, etc. We have characterized and reported 89 different cell lines since 1987. These cell lines have been distributed to biomedical researchers through the KCLB (Korean Cell Lines Bank). Some cell lines have several distinguishing characteristics; i) two hepatocellular cell lines (SNU-354 and -368) expressing the MDR1 gene and hepatitis B virus, ii) Gastric carcinoma cell lines with mutations in TGF-beta type II receptor gene, iii) uterine cervical carcinoma cell line (SNU-1000) having intact episomal HPV-16, and iv) ovarian carcinoma cell line (SNU-251) have a nonsense mutation of codon 1815 in exon 23 of the BRCA1 gene. The distributed SNU cell lines have proven to be of value in various scientific research fields.
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PMID:SNU cell lines and their application for cancer research. 1189 Jan 21

A 57-year-old woman had previously undergone a living-donor liver transplantation (LDLT) for end-stage liver disease related to hepatitis B virus. The liver graft had been donated by her husband. Her postoperative course had been uneventful. In the course of postoperative surveillance, she was incidentally found to have gastric cancer by an endoscopic examination 2 years after the liver transplantation. A gastric resection was the treatment choice, and the results were successful. The tumor, which was moderately differentiated adenocarcinoma, was limited to the mucosal layer, with no metastasis. In addition, a Helicobacter pylori infection was observed. This is the first reported case of a gastric cancer after LDLT. We report this case because of its importance regarding the need to carry out close surveillance in transplant recipients who are treated with immunosuppressive drugs, in order to make a timely identification of the occurrence of common malignancies.
Gastric Cancer 2007
PMID:Experience of gastric cancer in a patient who had received a living-donor liver transplantation. 1792 98