Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019163 (hepatitis B)
 38,309 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Leptospirosis is a ubiquitous, spirochetal zoonosis which presents with a broad clinical spectrum. Weil's syndrome, characterised by jaundice, renal failure and bleeding manifestations is the most severe form. A high index of suspicion for the diagnosis is required to institute therapy promptly. We describe a case of serologically confirmed Weil's syndrome with concomitant hepatitis B infection.
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PMID:Weils' syndrome and concomitant hepatitis B infection. 1041 69

Despite the availability of vaccines against hepatitis A and B, acute viral hepatitis due to these agents continues to be among the most commonly reported notifiable infectious diseases in the United States. Currently available hepatitis A and B vaccines are highly immunogenic and well tolerated, but vaccine coverage needs to be expanded. Use of the hepatitis A vaccine in children age 2 years and older should be more widespread than is currently the case. Hepatitis A vaccine has been shown to be cost effective when given to children in regions with high attack rates and to patients with chronic hepatitis C. Routine newborn immunization against hepatitis B has been a successful approach to disease control and is among the most cost-effective interventions. Use of the hepatitis B vaccine for all sexually active individuals with more than one sex partner should be recommended for this sexually transmitted disease. The availability of a combined hepatitis A and B vaccine should facilitate vaccine coverage in those individuals at risk for both infections. For those hepatitis infections for which no vaccine is currently available, namely hepatitis C, D, and E, reducing exposure risk by modifying lifestyle behaviors is the only control measure available. Early education and counseling about high-risk behaviors for the acquisition of blood-borne hepatitis viruses needs to be expanded to young children and adolescents. The eventual eradication of hepatitis virus infections through universal immunization is plausible for those agents for whom human beings are the only host and effective vaccines have been developed. If hepatitis E is shown to be a zoonosis with an extensive reservoir in pigs, eradication of this agent may be very difficult.
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PMID:Prevention of Viral Hepatitis. 1240 82

Investigation was undertaken to assess the occurrence of zoonotic infection among staff at Auckland Zoological Park, New Zealand, in 1991, 2002 and 2010. Serial cross-sectional health surveys in 1991, 2002 and 2010 comprising a health questionnaire, and serological, immunological and microbiological analysis for a range of potential zoonotic infections were performed. Laboratory results for zoo animals were also reviewed for 2004-2010 to assess the occurrence of potential zoonotic infections. Veterinary clinic, animal handler, grounds, maintenance and administrative staff participated in the surveys, with 49, 42 and 46 participants in the 1991, 2002 and 2010 surveys, respectively (29% of total zoo staff in 2010). A small number of staff reported work-related infections, including erysipelas (1), giardiasis (1) and campylobacteriosis (1). The seroprevalence of antibodies to hepatitis A virus and Toxoplasma gondii closely reflected those in the Auckland community. No carriage of hepatitis B virus (HBV) was detected, and most of those with anti-HBV antibodies had been vaccinated. Few staff had serological evidence of past leptospiral infection. Three veterinary clinic staff had raised Chlamydophila psittaci antibodies, all < 1 : 160 indicating past exposure. Two staff (in 1991) had asymptomatic carriage of Giardia lamblia and one person (in 2010) had a dermatophyte infection. After 1991, positive tests indicating exposure to Mycobacterium tuberculosis were < 10%, comparable to the general New Zealand population. Zoo animals had infections with potential zoonotic agents, including G. lamblia, Salmonella spp., Campylobacter spp. and T. gondii, although the occurrence was low. Zoonotic agents pose an occupational risk to zoo workers. While there was evidence of some zoonotic transmission at Auckland Zoo, this was uncommon and risks appear to be adequately managed under current policies and procedures. Nevertheless, ongoing assessment of risk factors is needed as environmental, human and animal disease and management factors change. Policies and procedures should be reviewed periodically in conjunction with disease monitoring results for both animals and staff to minimise zoonotic transmission.
Zoonoses Public Health 2012 Dec
PMID:Investigation of zoonotic infections among Auckland Zoo staff: 1991-2010. 2263 28