Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019163 (hepatitis B)
 38,309 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Longitudinal data on 2,125 participants in the Multicenter AIDS Cohort Study (MACS) with documented antibodies to the human immunodeficiency virus type 1 (HIV-1) were used to examine the incidence of acquired immune deficiency syndrome (AIDS)-related Kaposi's sarcoma (KS) over time and to determine if sexual practices and hematologic variables prior to diagnosis differed for participants who develop KS vs. non-KS AIDS (NKS). In the first 4 years of the study, 84 seropositive men were observed to develop KS and 307 presented with an AIDS diagnosis other than KS. A systematic trend in the incidence of KS over time was not apparent in this population. The number of anal-receptive intercourse partners prior to diagnosis declined in a similar fashion for both AIDS groups. Although the number of partners with whom the men performed rimming decreased prior to diagnosis for both AIDS groups, a greater proportion of the KS AIDS group had performed this activity with multiple partners than had the non-KS AIDS group. Furthermore, history of oral gonorrhea was significantly (p = 0.027) more prevalent in the KS group. In addition, the KS AIDS group had lower cytomegalovirus antibody levels prior to diagnosis and higher levels of total immunoglobulin G. The groups did not differ with respect to baseline hematological measures, temporal trends in helper and suppressor T cells, or hepatitis B surface antigen or antibody. Given this profile of factors associated with the occurrence of KS, an infectious agent, in addition to HIV-1, is plausible as a proposed cofactor in the development of KS.
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PMID:Incidence of Kaposi's sarcoma in a cohort of homosexual men infected with the human immunodeficiency virus type 1. The Multicenter AIDS Cohort Study Group. 239 82

During a three-week period in March/April 1987, the authors examined 253 consecutive patients referred to a rural hospital in northwestern Tanzania. Sera were tested for antibodies to human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), and human T-lymphotropic virus type I (HTLV-I), as well as for various parasites, hepatitis B virus, and Treponema pallidum. Neopterin (urinary and serum) was chosen as the immunologic parameter. In eight of the 253 patients (3.2%), a clinical diagnosis of acquired immunodeficiency syndrome (AIDS) was established. Three of the AIDS patients had HIV-1 antibodies, two had HIV-1 antigen, one had both HIV-1 and HIV-2 antibodies, and in one patient, only HIV-2 antibodies were found. The total HIV-1 and HIV-2 seroprevalence (antibodies plus antigen) was 4.3%; HTLV-I seroprevalence was 9.9%. No correlation could be found between HIV (or HTLV-I) seropositivity and raised levels of antibody to the above pathogens. There was, however, a significantly positive correlation between HIV seropositivity and history of gonorrhea, whereas a history of operations, injections, vaccinations, blood transfusions, or scarification did not influence the level of HIV seropositivity. The most frequently noted epidemiologic association with HIV seropositivity was traveling to or coming from Uganda or Rwanda. Two thirds of the studied Tanzanians had elevated neopterin levels, and all seven HIV-seropositive patients with clinical signs of AIDS had extremely high serum and urinary neopterin levels compared with HIV-seropositive patients without signs of AIDS. Increased neopterin levels reflect a stimulation of the T-cell/macrophage system.
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PMID:Retroviral infections (HIV-1, HIV-2, and HTLV-I) in rural northwestern Tanzania. Clinical findings, epidemiology, and association with infections common in Africa. 254 23

Forty asymptomatic homosexually active men seen at a Boston community health center and 39 men with generalized lymphadenopathy were interviewed and filled out detailed epidemiologic questionnaires. Twenty percent of the asymptomatic men and 92 percent of those with lymphadenopathy had antibodies to human T lymphotropic virus type III (HTLV-III). None of the men have subsequently had the acquired immune deficiency syndrome (AIDS). Seropositivity was associated with receptive anal intercourse and oral exposure to ejaculate, a history of hepatitis B, anal gonorrhea, or intestinal parasites, but no other sexually transmitted diseases, and did not correlate with the use of recreational drugs. More of the seropositive men had multiple partners from New York City. An association with seropositivity was less evident in relation to the numbers of partners from San Francisco or Los Angeles, since the whole cohort generally had fewer contacts with partners from these cities. The data suggest that educational programs among homosexual men attempting to decrease AIDS risk should focus on decreasing the number of partners, receptive anal intercourse, oral exposure to ejaculate and other intimate rectal contact, and sexual contact with men from areas of increased HTLV-III seroprevalence.
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PMID:Association of human T lymphotropic virus type III antibodies with sexual and other behaviors in a cohort of homosexual men from Boston with and without generalized lymphadenopathy. 300 86

A twenty six year old homosexual male with the diseases Hepatitis B, Lues, Gonorrhoea, ascending myelitis, lymphadenitis got additionally a chronic-inflammatory bowel disease, which first was discussed as Crohn's disease. Two "attacks" were "successfully" treated with Methylprednisolone. The patient died twelve month later in the follow of a pneumocystitis carinii pneumonia. The cause of the symptoms of the chronic-inflammatory bowel disease was a cytomegalovirus infection with acquired immune deficiency-syndrome.
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PMID:[AIDS--Crohn disease as a diagnostic error. Case report]. 301 28

Although recent data have supported the role of heterosexual activity in the transmission of hepatitis B virus infection in women, studies generating these data have enrolled few black women. We therefore examined black female participants attending our local health department's sexually transmitted disease clinic for the treatment of presumed uncomplicated gonorrhea in serologic and risk-factor surveys of hepatitis B virus infection. Twenty-four (17.6%) of 136 subjects tested had evidence of prior hepatitis B infection. Serologic evidence of hepatitis B infection was significantly associated with three different barometers of sexual activity that included: (1) years of sexual activity (P less than 0.005); (2) history of sexually transmitted disease (P less than 0.02); and (3) number of lifetime heterosexual partners (P less than 0.001). These data provide further support that the quantity of sexual exposure seems to be an important risk factor for hepatitis B infection in heterosexually active females.
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PMID:Risk factors for hepatitis B virus infection in black female attendees of a sexually transmitted disease clinic. 322 74

Routine obstetric screening for all patients should include a Pap smear, urinalysis and urine culture, complete blood count, blood type, Rh factor and direct Coombs' test. Patients should also be screened for syphilis, rubella, gonorrhea and diabetes. For patients at high risk for certain conditions, additional studies of value include obstetric ultrasound, amniocentesis, serum alpha-fetoprotein level and screening for sickle cell anemia, herpes, hepatitis B, Chlamydia and human immunodeficiency virus.
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PMID:Prenatal screening. 328 2

The changing epidemiology of neonatal infections manifested in the first few weeks of life is described. The six infections discussed are herpes, hepatitis B, chlamydial infection, infection due to the group B streptococcus, gonococcal disease, and acquired immunodeficiency syndrome. Nursing actions to prevent the spread of these diseases are described, with particular emphasis on the importance of body substance precautions for all neonates.
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PMID:Trends in neonatal infections. 332 Feb 99

235 homosexual men participated in a prospective study conducted in Helsinki, Finland, in 1983-86 aimed at identifying associations between sexually transmitted diseases (STDs), condom use, and human immunodeficiency virus (HIV) infection. The mean observation time was 22.7 months and the average age of study participants was 35.3 years. Of the 235 men, 27 (12%) gave no history of previous STD at the 1st examination. The remainder reported at least 1 STD, the most common being pubic lice (65%), gonorrhea (43%), and nongonococcal urethritis (26%). The 31 men (13%) who were seropositive for HIV infection at the end of the study had experienced significantly more STD episodes than seronegative subjects. All 9 of the seroconversions considered to have taken place during the study period involved men whose sexual behavior included unprotected receptive or insertive intercourse into the mouth or rectum. No HIV infection emerged among the men who practiced safe sex practices--monogamous sex with an HIV seronegative partner, no mucosal contact during sex, or the consistent use of condoms during anal sex. There was a weak association between HIV and hepatitis B infection, but a strong link between HIV and the prevalence of hepatitis B c antibodies. The statistically significant association observed in this sample between HIV seropositivity and heavy exposure to STDs may either reflect an enhanced probability of encountering HIV along with other pathogens or the role of other STDs as cofactors in HIV infection. The decreasing incidence of STDs observed during the follow-up period reflects counseling about risk reduction that was provided as part of the study. By the end of the study period, almost half the men had stopped practicing anal sex and almost 1/3 were using condoms. However, further spread of HIV can be expected in Finland given the fact that 57% of study subjects were still practicing anal sex at the end of the follow-up, the majority of them without condoms.
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PMID:Sexually transmitted diseases and the use of condoms in a cohort of homosexual men followed since 1983 in Finland. 339 35

In 1985, 132 female prostitutes and 55 female nonprostitutes at a sexually transmitted disease (STD) clinic in Sydney, Australia requested to be tested for HIV antibodies and completed a questionnaire covering a wide range of social and medical issues. The 2 groups were matched for age and were similar in other respects, excluding the number of sexual partners. Laboratory personnel tested the serum using the ELISA test and confirmed by the H9 exclusionary ELISA and by immunofluorescence using a T cell line infected with HIV. All the women tested seronegative for HIV antibodies. 19% of the prostitutes and 24% of the nonprostitutes had used IV drugs. A substantial number of women from both groups reported using 1 or more other drugs. 37% of the prostitutes and 45% of nonprostitutes claimed to not have used any of the illegal drugs listed in the questionnaire, during the preceding 6 months. 29% of the prostitutes and 33% of the nonprostitutes recorded partners at risk from IV drug use. The number of sexual partners reported by the 2 groups in the month prior to the survey ranged from 1-250 (median 24.5) for prostitutes and 0-4 (median 1.50) for nonprostitutes. For a 1 year period the corresponding figures included 1-3000 (median 175) for prostitutes and 1-13 (median 3.5) for nonprostitutes. More than 1/3 reported having bisexual partners during the previous 5 years. Prostitutes had significantly more episodes of gonorrhea, chlamydial infection, and pelvic inflammatory disease than the nonprostitute group (p.05). 1/2 of the 8 prostitutes who had hepatitis B were IV drug users. 76% of nonprostitute partners and 49% of prostitute partners did not use condoms. Despite the fact that HIV antibodies were not detected in these women, the researchers concluded that HIV could spread rapidly within the prostitution population and back into the wider community through sexual contacts and IV drug use. Current control measures need to be enhanced and the medical community needs to continue to monitor prostitutes' health.
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PMID:Human immunodeficiency virus and female prostitutes, Sydney 1985. 341 Apr 67

Physicians treating adolescents should take a complete sexual history, including sexual orientation and practices, to determine whether their patients are homosexually active. Lesbians are at very low risk for sexually transmitted diseases, but they do have other health concerns. Four general groups of conditions may be encountered in homosexually active men: classical sexually transmitted diseases (gonorrhea, infections with Chlamydia trachomatis, syphilis, herpes simplex infections, genital warts, pubic lice, scabies); enteric diseases (infections with Shigella species, Campylobacter jejuni, Entamoeba histolytica, Giardia lamblia, hepatitis A, hepatitis B, hepatitis non-A, non-B, and cytomegalovirus); trauma (fecal incontinence, hemorrhoids, anal fissure, foreign bodies, rectosigmoid tears, allergic proctitis, penile edema, chemical sinusitis, inhaled nitrite burns, and sexual assault of the male patient); and the acquired immunodeficiency syndrome (AIDS). Clinicians can assist homosexual teenagers by understanding their special health needs, by counseling them about safe sexual practices, and by accepting their relationships nonjudgmentally.
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PMID:Medical problems of the homosexual adolescent. 383 19


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