Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019163 (hepatitis B)
 38,309 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 59-year-old woman was admitted to our hospital with acute onset of chest pain. She had experienced high fever, weight loss, polyarthralgia, myalgia, polyneuropathy and hallucinations for 3 years before admission. The diagnosis of polyarteritis nodosa with hepatitis B surface antigenemia was made by muscle biopsy and serological examinations, and administration of prednisolone induced remission of all the manifestations. After developing the acute attack of severe chest pain, she died suddenly. At autopsy, a DeBakey type 1 aortic dissection was found and the immediate cause of death was found to be cardiac tamponade secondary to rupture of the aortic dissection. Microscopically, necrotizing inflammatory lesions were present in the medium sized vascular arteries throughout her body. Furthermore, necrotizing vasculitis was also found in the vasa vasorum of the adventitia and media of the thoracic aorta. The dissecting lesion was seen in the outer layer of the media. Our results suggest that spontaneous dissection of the aorta may be attributed to necrotizing vasculitis of the vasa vasorum.
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PMID:Polyarteritis nodosa with aortic dissection: necrotizing vasculitis of the vasa vasorum. 136 Dec 5

Acupuncture has been widely performed for the treatment of many different disorders in Japan. Several complications of acupuncture such as pneumothorax, cardiac tamponade, serum hepatitis have been reported. Accidentally broken needle is also one of the causes of complications of acupuncture. Usually it produces little problem, but may cause spinal cord injury, as presented by this report. The patient was a 49-year-old man who received an acupuncture procedure in his left nuchal region for shoulder pain. During acupuncture the needle was accidentally broken. The needle was tried to be removed by a surgeon on the same day but it could not be found. He was seen at our hospital with no neurological deficit 3 month later. Plain X-ray films and CT scan revealed a 4 cm long needle between C2 and C3 vertebrae penetrating into the cord. The needle was removed to prevent the possible neurological deficit which might be produced by the moving needle. The operative procedure was done under operating microscope with the aids of X-ray monitoring and injected dye. The direction to reach the tail of the broken needle is most important for avoiding further spinal cord injury during procedure. The post-operative course of the patient was uneventful and he was discharged with no deficit.
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PMID:[Spinal cord injury by a broken acupuncture needle--a case report]. 374 87

Melioidosis is endemic in Taiwan. It is caused by infection with Burkholderia pseudomallei. A prolonged course of oral eradication therapy to avoid relapse after an intensive intravenous therapy is recommended to treat melioidosis. Melioidosis with cardiac involvement is rare and is often combined with septicemia, for which the mortality rate is 20-60%. The initial clinical presentations of melioidosis mimic Mycobacterium tuberculosis infection, which is the most common etiology of bacterial pericarditis in Taiwan. We present a case of non-septicemic melioidosis that presented as non-suppurative cardiac tamponade and left subcarinal lymphadenopathy. Underlying diseases included hepatitis B-related liver cirrhosis and hepatocellular carcinoma. The patient was successfully treated with 2 weeks of intravenous ceftazidime and 12 weeks of oral doxycycline, trimethoprim-sulfamethoxazole, and amoxicillin/clavulanate. Melioidosis-related pericarditis should be considered in the differential diagnoses of bacterial pericarditis in Taiwan.
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PMID:Non-septicemic melioidosis presenting as cardiac tamponade. 1878 43