Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Prajmalium rarely causes idiosyncratic liver injury. Author describes the case of cholestatic hepatitis occurring in three weeks after cessation of short-term treatment with prajmalium. Eighteen months later, despite of good general status, physical and biochemical features of cholestasis were present. Pathologic examination of liver biopsy specimen revealed the chronic intracellular cholestasis with lymphocytic infiltration. Presented case indicate that even short-term treatment with potentially weekly hepatotoxic drug may cause the long-term intrahepatic cholestasis.
Pol Arch Med Wewn 2003 Jun
PMID:[Cholestatic hepatitis caused by prajmalium treatment: case report]. 1456 96

HCV infection results in chronic hepatitis in most patients. The mechanisms determining liver damage and the events that lead to a high rate of chronic hepatitis remain unclear. In present study, an attempt was made to sum up data on lesions in the liver in the course of chronic type C hepatitis including those of our own cases, because that pattern is still a matter of debate. Cell lesions detected by light microscopy are characteristic but not specific and included inflammatory lesions of low or moderate intensity and a mild extent of fibrosis in the liver. The common and most characteristic trait of chronic HCV infection involves lesions in hepatocyte nuclei. These changes involved swelling, altered shape, hyperchromasia, disturbed nuclear chromatin structure, enlarged and frequently multiple nucleoli and lesions of nuclear envelope. Complexes of tubules or branching fibrils of 20-30 nm in diameter were present in cell nuclei at electron microscope level. The nuclear lesions were accompanied in the same cells by changes in rough endoplasmic reticulum with long tubular structures or branching fibrills inside. Other cytoplasmic changes included mitochondrial lesions, numerous lipid vacuoles and free tubular structure of a highly osmophilic character. Cellular localisation of HCV proteins using immunocytochemical techniques remains to be a matter of studies. In most studies HCV proteins have been detected in the cytoplasm although some reports indicate nuclear localisation, especially of C protein. All our observations on morphological lesions in chronic type C hepatitis can generally confirm most of data of other authors, but the criteria of nuclear lesions defined at the ultrastructural level represent the original input of our studies. The studies using molecular biology techniques should be continued at the electron microscope level.
Pol J Pathol 2003
PMID:Morphological lesions detected by light and electron microscopies in chronic type C hepatitis. 1457 22

We report two cases of successful pregnancies in women after liver transplantation for end-stage liver dysfunction caused in one case by Wilson disease and in the second one by lupoid hepatitis. For woman with the Wilson disease it was a second pregnancy and for woman with lupoid hepatitis it was the first pregnancy. Mothers continued immunosuppressive therapy during their pregnancies. Labours started spontaneously at 39th and 36th week's of gestation. As a result the healthy two female infants weighing 3600 g and 2420 g respectively were born. The first woman with her baby was discharged from hospital on the third day after delivery and the second one and her baby on the sixth day after delivery. Both were in good condition.
Ginekol Pol 2003 Oct
PMID:[Pregnancy, delivery and puerperium in patients after liver transplantation]. 1466 25

In acute stage of virus hepatitis B patients often complain of dyspeptic discomfort. They may be a consequence of alimentary tract motor activity disorders including these of gallbladder. Routine ultrasonography in an early phase of virus hepatitis often reveals gallbladder wall thickening what may confirm the above thesis. Thus, a group of 15 patients in an acute phase of virus hepatitis B was subjected to examinations. Gallbladder motor activity was assessed by ultrasonographic method determining its total volume and ejection fraction and volume after test meal stimulus. First examination was performed in the first week since the appearance of yellowing of the walls, successive in 4 and 8 week of the disease. Obtained results were compared to the values obtained in the group of 25 healthy volunteers. It was found out that gallbladder volume was significantly decreased and ejection fraction increased in the acute phase of virus hepatitis B than in the controls. This may speak for gallbladder hyperreactivity in patients in the course of virus hepatitis B. These disorders decreased during two-month observation but even in the 8 week the investigated parameters differed from those found in the control group.
Pol Merkur Lekarski 2003 Dec
PMID:[Gallbladder motor activity in patients with virus hepatitis B]. 1505 48

Intrinsic to the life cycle of hepatitis delta virus (HDV) is the fact that its RNAs undergo different forms of posttranscriptional RNA processing. Transcripts of both the genomic RNA and its exact complement, the antigenomic RNA, undergo ribozyme cleavage and RNA ligation. In addition, antigenomic RNA transcripts can undergo 5' capping, 3' polyadenylation, and even RNA editing by an adenosine deaminase. This study focused on the processing of antigenomic RNA transcripts. Two approaches were used to study the relationship between the events of polyadenylation, ribozyme cleavage, and RNA ligation. The first represented an examination under more controlled conditions of mutations in the poly(A) signal, AAUAAA, which is essential for this processing. We found that when a separate stable source of deltaAg-S, the small delta protein, was provided, the replication ability of the mutated RNA was restored. The second approach involved an examination of the processing in transfected cells of specific Pol II DNA-directed transcripts of HDV antigenomic sequences. The DNA constructs used were such that the RNA transcripts were antigenomic and began at the same 5' site as the mRNA produced during RNA-directed HDV genome replication. A series of such constructs was assembled in order to test the relative abilities of the transcripts to undergo processing by polyadenylation or ribozyme cleavage at sites further 3' on a multimer of HDV sequences. The findings from the two experimental approaches led to significant modifications in the rolling-circle model of HDV genome replication.
 ...
PMID:Alternative processing of hepatitis delta virus antigenomic RNA transcripts. 1507 32

Interleukin 18 has been known since 1989 and since its properties have been recognized, an interest in it is constantly growing. IL-18 induces synthesis and release of proinflammatory cytokines, chemokines and nitric oxide. Thus, it modulates the function of many immunocompetent cells: macrophages, monocytes, lymphocytes and granulocytes. In the paper, properties of IL-18 are reviewed and its implications for pathogenesis of some gastrointestinal diseases, particularly inflammatory bowel diseases, i.e. Crohn Disease and colitis ulcerosa, inflammatory liver diseases such as persistent active hepatitis and primary biliary cirrhosis and acute pancreatitis are discussed.
Pol Merkur Lekarski 2004 Mar
PMID:[Interleukin 18 as a new immunomodulator of some digestive tract diseases]. 1519 Jun 10

The potential for blood contact with skin puts operating room personnel at increased risk of exposure to hepatitis or HIV virus. One of the most common areas of contamination with infectious biological material is the hands and fingers due to failure of glove protection. There are varying opinions regarding the frequency of glove failure during orthopaedic procedures and the necessity of wearing two gloves for added protection. The authors performed a trial of 94 procedures involving 10 surgeons from Orthopaedic Department of Pomeranian Medical University from Szczecin, Poland to answer these questions. Outer-glove perforations occurred in 15% of the cases while inner-glove--in only 3.1% (p < 0.0001). In 5 cases there was an inner-glove defect without a corresponding outer-glove perforation. Both the duration of the operation longer than 2 hours and the type of the procedure (minor versus major) were associated with increased rates of perforation (p < 0.002 and p < 0.0007 respectively). From total amount of perforated outer-gloves, only 13 (28%) were changed by the surgeon during the operation. There was no statistically significant difference between latex and neoprene used as inner-gloves (p > 0.17) in failure rates. The authors conclude double gloving during orthopaedic procedures and changing the gloves every 2 hours may significantly reduce the operating room personnel's risk of exposure to blood borne pathogens.
Chir Narzadow Ruchu Ortop Pol 2004
PMID:[Double gloving in reducing the interoperative risk of blood borne pathogens]. 1558 81

The present study was designed to examine the effects of the donor of nitric oxide (NO), NaNO(2) and the inhibitor of NO synthase, N(omega)-nitro-L-arginine (L-NNA), on the development of dimethylnitrosamine (DMNA)-induced chronic hepatitis in rats. L-NNA decreased rat survival and enhanced the severity of hepatic encephalopathy in the DMNA-treated animals. The aggravation of the morphological signs of hepatitis, the activation of serum alanine aminotransferase and cytosolic superoxide dismutase activities and the increase in the liver malondialdehyde content were observed in this group. The treatment with NaNO(2) improved liver morphology, decreased serum marker enzyme activities, lowered the activities of alpha-D-mannosidase and N-acetyl-beta-D-glucosaminidase compared to the DMNA-treated group. The results of the morphological and biochemical studies suggest that L-NNA increased DMNA-induced liver damage, whereas NaNO(2) partially prevented the development of chronic hepatitis. It is proposed that the opposite effects of L-NNA and NaNO(2) are partially explained by a modulation of the free radical-dependent processes in the liver.
Pol J Pharmacol
PMID:Effect of the nitric oxide donor and the nitric oxide synthase inhibitor on the liver of rats with chronic hepatitis induced by dimethylnitrosamine. 1559 49

Reactivation of varicella-zoster virus (VZV) usually leads to developing of characteristic skin lesions with dermatomal distribution. In very rare cases typical clinical picture can be absent, which impairs diagnostic procedure. Atypical case of young non HIV infected man was described. Clinical picture of meningitis and hepatitis due to VZV reactivation without typical skin eruptions resulted in diagnostic problems and required differentiation with proliterative process. Essential role of serologic testing in such cases was emphasized.
Pol Merkur Lekarski 2004 Sep
PMID:[Diagnostic problems in the course of varicella-zoster virus reactivation leading to meningitis and hepatitis--case report]. 1562 58

The case of simultaneous clinical manifestation of autoimmune hepatitis (AIH) and autoimmune thyroiditis was described. The authors presented diagnostic difficulties often related to AIH. The interdependence between the liver and thyroid gland function was emphasized. Correlative occurrence of different diseases of autoimmune origin in the same patients indicates a particular genetic predisposition.
Pol Arch Med Wewn 2004 Dec
PMID:[Simultaneous occurrence of autoimmune hepatitis type III and autoimmune thyroiditis type III (Graves disease)]. 1596 13


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>