Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this study we present a 12-year-old girl with chronic C hepatitis coinfected with HGV, in which severe life-threatening side effects from alfa interferon therapy occurred after 3 months of injection and required definite IFN withdrawal. It seems, that infection HGV may predispose patients with chronic C hepatitis treated with alpha interferon to this severe side effect.
Pol Merkur Lekarski 1999 Jul
PMID:[Chronic hepatitis C in a 12-year-old girl coinfected with HGV]. 1052 7

The aim of the study was to evaluate epidemiology and clinical course of HCV infection in children and adolescents with end-stage renal disease. The study involved 70 patients, aged 1-25 years, 31 M, 39 F: group of 40 dialysed (27 HD, 13 CAPD) and 30 patients suffering from different chronic renal disease as a control group. Anti-HCV antibodies were assayed by EIA 3rd gene (Abbott Diagnostic) and were sought by LIATEK HCV 3rd gene. HCv RNA was detected and measured by a standardised HCV RNA PCR assay (Amplicor Roche). HCV genotypes were identified by InnoLIPA (Innogenetics). HCV infection was diagnosed in 20 (50%) dialysed and in 3 (10%) non-dialysed patients. None of the HCV infected patients presented the clinical symptoms of hepatitis; the mild activity of ALT was observed in 8 cases only. HCV viremia was relatively low: 365 x 103 copies/mL in PD and 110,9 x 103 copies/mL in HD patients. 3 genotypes of HCV were identified: 1a, 1b and 4c/4d. In 3 cases liver biopsy was performed, no cirrhosis was diagnosed.
Pol Merkur Lekarski 2000 Apr
PMID:[Epidemiology and clinical course of HCV infection in children and adolescents with chronic renal failure]. 1089 36

Measurement of antimitochondrial antibodies is established as a sensitive indicator for primary biliary cirrhosis, which has unfortunately limited diagnostic specificity. M2-antigen complex, consisted of four proteins of the inner mitochondrial membrane, has been found to be strongly associated with PBC. Clinical value of anti-M2 antibodies quantitative measurement with ELISA was analysed in 107 patients with carefully diagnosed liver diseases: acute viral hepatitis A, B, C (VHA, VHB, VHC; n = 41), chronic viral hepatitis B, C (CHB, CHC; n = 23), autoimmune hepatitis (AH; n = 6), liver cirrhosis (LC; n = 20), extrahepatic cholestasis (EC; n = 2) and primary biliary cirrhosis (PBC; n = 15). The highest values were found in PBC patients and varied from 92 to 167 U/l and dramatically exceeded normal range recommended by manufacturer (5 U/l). Mean value in this group (119.5 +/- 8.4 U/l) was significantly (p < 5 x 10(-8)) higher than in others, that varied from 1.3 +/- 0.2 up to 2.8 +/- 1.7 U/l in VHA and CHC groups respectively. Only two among 92 non-PBC patients have values over 10 U/l, but they reached only 15.8 (CHB) and 16.5 (CHC). Anti-M2 level in PBC patients demonstrated a significant positive correlation (r = 0.857) with the degree of liver insufficiency measured trough Child-Pugh score. From these data we can conclude, that quantitative measurement of anti-M2 antibodies with ELISA can serve as a very good screening for PBC, with 100% diagnostic sensitivity and specificity, if concentration of 20 U/l will be established as a pathognomic level.
Pol Merkur Lekarski 2000 Jun
PMID:[Antibodies against M2-antigen in differential diagnosis of primary biliary cirrhosis]. 1096 9

In this study we present the analysis of pathological pictures of the liver in children with chronic HCV infection, among whom 60 children with HCV RNA and 22 children without HCV RNA were selected. For histological evaluation traditional classification and modified Histological Activity Index (HAI) was used. Only 2 children without viremia did not present changes in histopathological picture, in the remaining ones with and without viremia hepatitis chronic persistent prevailed. In both groups of children statistical differences in necroinflammatory activity and fibrosis were not observed. In histopathological picture correlation grading and staging was observed. The results of the studies show necessity for histological evaluation in anti-HCV carriers, because the pathology of the liver may occur independent of viremia.
Pol Merkur Lekarski 2000 Jun
PMID:[Histological evaluation of activity and progression changes in the liver in HCV infected children]. 1096 12

Cytomegalovirus (CMV) is widespread. In most cases CMV infection is asymptomatic. The most significant clinical syndrome is mononucleosis and hepatitis. We report a case of 38 old woman with CMV hepatitis associated with erysipelas.
Pol Merkur Lekarski 2000 Nov
PMID:[Acute hepatitis caused by cytomegalovirus]. 1120 29

Hepatitis delta virus (HDV) is a defective RNA virus with similarities to unusual subviral pathogens of higher plants. It requires hepatitis B virus (HBV) for its replication/transmission, and HBV-infected humans are the only established host. HDV causes both severe acute hepatitis and rapidly progressive chronic disease in some individuals. The HDV life cycle involves remarkable features, such as ribozyme- mediated autocatalytic processes, Pol II-directed RNA synthesis from a single-stranded circular RNA template, and RNA editing. Much of our understanding of the nature of this pathogen derives from experimental studies in the chimpanzee model of HBV infection. The hepadnavirus-infected eastern woodchuck also is capable of supporting HDV replication and offers opportunities for the development of control strategies that might be applicable to human type D hepatitis.
 ...
PMID:Animal models of hepatitis delta virus infection and disease. 1140 12

To characterize the toxicity of phosphorothioate antisense oligodeoxynucleotides ([S]ODNs) in vivo, the mice received intravenously 26-mer bcr-abl antisense oligodeoxynucleotides (1 mg/mice/day) for 9 consecutive days. The organs and tissues were removed on the indicated days (+1, +7, +30) after the treatment. Our investigation revealed middle elevation of aminotransferases activity, lactate dehydrogenase level, total protein level and globulin level, decrease of glucose, albumin and blood urea nitrogen level in the peripheral blood. The mild anaemia and thrombocytopenia were observed too. The most significant treatment-related findings in the antisense treated mice were splenomegaly, reactive hepatitis and atrocytosis of kidney. These findings together with previous results demonstrate little and temporary toxicity effects mainly in organs known from cumulating of [S]ODNs.
Pol Arch Med Wewn 2001 May
PMID:[Adverse effects of parenteral administration of antisense oligonucleotides]. 1186 87

The possibility of amplification of human cytomegalovirus (HCMV) DNA in cerebrospinal fluid (CSF) for the diagnosis of HCMV central nervous system (CNS) infection in infants was studied. Single-step PCR, nested PCR and PCR-Digene were used to assay CSF specimens from 37 patients. Criteria for patient inclusion in the study were: 1. clinical manifestations suggesting CMV neuroinfection such as seizures, hypertonia, hypotonia, intracranial calcification, microcephaly, chorioretinitis; 2. any of the following symptoms: anaemia, hepetomegaly, prolonged cholestatic jaundice, or hepatitis, splenomegaly, thrombocytopenia, intrauterine hypotrophy; 3. serologic presentation, and/or positive results for CMV infection obtained by single-step PCR and PCR-Digene in urine and/or blood. PCR-Digene results were positive in 6 CSF samples. Four CSF samples were positive by nested PCR and 1 CSF sample by single step PCR. We found that the double PCR was about ten or more times more sensitive than single PCR and the PCR-Digene was only three times more sensitive than nested-PCR. The results were correlated with serology. Thirty-three out of 37 examined patients were seropositive (ELISA IgG); ELISA IgM gave positive results in 9 patients. In control studies, cells infected with other members of the herpes virus family were negative with these methods, which suggest that amplification combined with primers from the IE and the L-region of CMV is specific. In conclusion, nested-PCR seems to be the best method for early diagnosis of CMV infection in CSF due to an absence of false positive results and its high specificity and sensitivity.
Acta Microbiol Pol 2001
PMID:Detection of cytomegalovirus in infant cerebrospinal fluid by conventional PCR, nested PCR and PCR-Digene. 1193 Sep 94

The author presents the review of world literature on infection of novel discovered SEN virus (SENV) after the initials of the infected patients, a human immunodeficiency virus-infected injection drug user. This single-stranded DNA virus, distantly related to the TT virus (TTV) has been announced as a major cause of non-A-E hepatitis. Genotypes SENV-D and SENV-H were more prevalent in the serum samples of patients with transfusion-associated hepatitis and were of lesser prevalence in serum samples from healthy blood donors.
Pol Merkur Lekarski 2002 Sep
PMID:[SEN virus--novel hepatotropic agent causing hepatitis?]. 1247 84

Apart from serological diagnosis of chronic type B hepatitis, of high importance is specific morphological diagnosis, based on evaluation of liver biopsies. In the evaluation, the techniques are employed, which directly visualize the virus in the cells (electron microscopy) as well as the techniques of cell biology which demonstrate the presence of viral genetic material and viral proteins in situ. This paper reviews the available data on the diagnosis of liver pathomorphology using the above mentioned techniques in chronic HBV infections in adults. The data have been compared with the results of our own studies, performed in children. In chronic type B hepatitis and more frequently in children than in adults, slight or moderate inflammation (grade 1 to 2) and insignificantly advanced fibrosis (stage 1 to 2) are noted in the liver. Both in children and in adults, lesions in hepatocyte nuclei represent the common morphological denominator in the patterns of light and electron microscopy. The cell nuclei are of variable size, irregular shape, they stain irregularly, manifest an altered outline of nuclear envelope, frequently exhibit numerous and enlarged cell nucleoli and chromatin dissociation (the so called empty cell nuclei). In ultrastructural studies, hepatocyte cytoplasm contains Dane's bodies and tubular forms of HBsAg while virus-resembling particles are noted in cell nuclei. Molecular biology techniques (immunocytochemistry, in situ hybridisation) reveals nuclear and/or cytoplasmic location of HBcAg, cytoplasmic location of HBsAg and a similar location of HBV DNA. The data permit us to determine precisely the stage of infection and to make appropriate therapeutic decisions.
Pol J Pathol 2002
PMID:Morphological lesions detected by light and electron microscopies in chronic type B hepatitis. 1247 11


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