Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

By means of counterelectrophoresis (CEP) HBs-Ag and anti-HBs were found in the serum of a patient with a third episode of virus hepatitis. Presence of HBs-Ag was confirmed by complement fixation (CF) and immunodiffusion (AGD) but the antibody was not demonstrated by these methods. The subtype of HBsAg in this case was ayw and the antibody was monospecific anti-HBs/d. The presence of HBsAg and anti-HBs differing in specificity was due, probably, to double infection with HB viruses of different subtypes--ayw and adw in this case.
Acta Haematol Pol
PMID:[Simultaneous presence of HB-s and anti-HB-s antibody with different specificity in serum]. 6 36

7 individual cases of hepatocellular damage caused by the use of oral hormonal contraceptives are examined. 3 different morphological patterns of damage were observed: reactive hepatitis, intrahepatic cholestasis, and subacute hepatitis. Discussion of the pathenogenesis of this damage revolves around the theory of competitive effect of sex hormones on the metabolism and transport of bilirubin, the theory of hypersensitivity, and theoretical toxic actions of contraceptive hormones. The reversibility of hepatocellular damage in 3 cases in the form of gestational hepatosis perhaps advocates the theory of hypersensitivity to endogenous and exogenous hormones. 1 case of subacute hepatitis had a lethal outcome, which suggests the possibility of direct toxic effects of hormonal contraceptives.
Pol Arch Med Wewn 1977 Aug
PMID:[Types of hepatocellular damage caused by contraceptives]. 90 63

The author observed a 20-year-old patient with selective aplasia of the erythrocytopoietic system developing during virus hepatitis and disappearing completely after one year.
Acta Haematol Pol
PMID:[Selective aplasia of erythropoietic system following viral hepatitis]. 112 42

Two groups of experimental animals, each consisting of 12 rabbits, were subjected to local fractional irradiation with cobalt 60. Group I received the total dose of 2580 R during 13 days, group II - 5100 R during 24 days. The effects of irradiation were estimated on the strength of histological examination of the liver immediately and after 7, 15, 30, 60 and 90 days after the last exposition. The histological sections were stained with haematoxylin and eosin, and colour reactions were performed for argentaffine and collagen fibres and for glycogen, neutral fats, alkaline and acid phosphatase, ATP-ase, glycose-6-phosphatase, non-specific esterase and succinic acid dehydrogenase. It was found that the dose of 2580 R is safe for the liver. The effects of irradiation were slight and limited to weak catabolic disturbances in the form of mild steatosis of the liver and of a transient and short-lived fall of glycogen and rise of hydrolytic enzymes. More pronounced and intense changes were observed in the other group of animals. During the early period, the changes were of a retrograde character and were typical of the acute post-irradiation effect. There was necrosis of the walls of the blood vessels, of the epithelium of the bile ducts and of the liver cells, accompanied by a rise in the hydrolytic enzymes and by a considerable fall of the level of glycogen and succinic acid dehydrogenase. During the late period (30-90 days), changes typical of the so-called post-irradiation hepatitis were found histologically.
Pol Arch Weter 1975
PMID:[Pathomorphological and histochemical changes in the liver of rabbits following fractional irradiation with Co-60]. 118 53

The results of the vaccination of dogs with Canivac F (distemper vaccine) and Canivac FH (distemper) hepatitis vaccine, are presented. The Canivac F vaccine was injected intravenously (i.v.) to 8 dogs, intramuscularly (i.m.) to 1 dog and subcutaneously (s.c.) to 1 dog. The Canivac FH was administered i.v. to 19 dogs, i.m. to 1 dog and s.c. to 18 dogs. All the dogs displayed no-postvaccination signs. Distemper antibodies were observed in blood sera of all dogs vaccinated with Canivac F after 9-10 and 20-21 days. In sera of dogs vaccinated with Canivac FH, distemper, antibodies were present in 14 of 18 serum samples after 9-10 days and in 26 of 27 samples after 20-21 days. The antibody titre did not depend on the vaccination route. The peak of antibody titre was observed after 37 to 51 days after vaccination. The hepatitis antibodies in dogs vaccinated with Canivac FH were found in 15 of 17 animals after 9-10 days, and in all 27 dogs examined after 20-21 days. On the basis of an intracerebral challenge with virulent distemper virus and by intraperitoneal challenge with virulent dog's hepatitis virus (Rubarth's disease), it was demonstrated that all the vaccinated dogs acquired the full immunity. In addition, it was found that vaccinated dogs kept in the environment contaminated naturally with Rubarth's disease virus were also resistant to the disease. All the non-vaccinated dogs were still susceptible to distemper or hepatitis infections. On the strength of the analysis of the obtained results and our previous studies, it can be assumed that Canivac F and FH vaccines produced in Poland are harmless and show a high immunogenic activity.
Pol Arch Weter 1975
PMID:[Antibody formation and resistance in dogs vaccinated intravenously and subcutaneously against distemper and Rubarth's disease]. 118 57

The study included 68 children aged from 1 to 16 years treated for acute leukemias and bone marrow aplasia. Cytomegalovirus antigen (CMV) was detected by immunofluorescence in urinary sediment cells and in cell cultures after their inoculation with CMV. Besides, the activity of IgG and IgM classes of antibodies against CMV was determined. Presence of one or more markers of CMV infection was demonstrated in 31 children, i.e., 45.5%. In eight children (11.7%) clinical manifestation of CMV infection were demonstrable with fever, hepatitis, pneumonia, rash. In all the children who completed the treatment with hyperimmune globulin, regression of clinical symptoms and signs of CMV infection with the elimination of virus antigen from urine was achieved.
Acta Haematol Pol 1992
PMID:Cytomegalovirus infection in children with blood diseases. 128 81

In the years 1980-1988 twenty five drug addicts were identified among 1841 patients hospitalized for acute hepatitis in the Dep. of Hepatology at the Institute of Infectious and Parasitic Diseases in Warsaw. 15 drug addicts had hepatitis B and 10 had hepatitis A. It was found, that the course of acute type B hepatitis was milder in drug addicts, than among control group consisting of non-addicts.
Pol Tyg Lek
PMID:[Hepatitis B among drug addicts]. 143 23

Non-A, non-B hepatitis has been diagnosed in 12 blood donors in a plasmapheresis unit. The course of the disease has been symptomatic, accompanied by jaundice, fatigue, and nausea in 8 cases, and subclinical in the remaining 4 patients. Nine patients were followed-up to 2 years and only 2 patients liver biochemical tests were normalized permanently. The biopsies performed, a year after the acute phase of hepatitis period revealed chronic active disease in patients, chronic persistent hepatitis in 2 patients, acute hepatitis in one, and normal liver in one patient. Repeated liver biopsies, performed one year later, have basically shown similar lesions except one patient in whom chronic active hepatitis progressed to incipient liver cirrhosis. No symptoms of the disease have been usually noted in patients with chronic form of the disease, and liver function tests have occasionally been normal.
Pol Tyg Lek
PMID:[Epidemic focus of non-A, non-B viral hepatitis in a plasmapheresis unit]. 143 24

A novelty of the present studies is the use of alpha 1-antitrypsin (A-1--AT) as an endogenous marker of enteric protein loss. Enteric clearance of alpha 1-antitrypsin was determined in 10 patients with the symptoms of PLE, and in 6 healthy individuals. Alpha 1-Antitrypsin concentration has been assayed in single, random samples of feces collected from 42 patients and 12 healthy individuals (normal values: 1.31 +/- 0.72 mg/g of feces). Markedly increased enteric clearance and A-1-AT concentrations in single, random samples of feces have been found in patients with enteric lymphangiectasis, Crohn's disease, ulcerative colitis, and constrictive pericarditis, slightly lower in coeliac, chronic diarrhoea, nonspecific hemorrhagic colitis, esophagitis, lambliasis, hypogammaglobulinemia, Wiskott-Aldrich syndrome, Rendu-Osler-Weber syndrome, hepatitis in newborn, and Gilbert's disease. Statistically significant positive clearance has been noted (r = 0.997; p less than .001). A single assay of A-1-AT in feces is simple, repeatable, and sensitive technique in the diagnosis and evaluation of these diseases in which the symptoms of enteric protein loss are seen.
Pol Tyg Lek
PMID:[Alpha 1-antitrypsin as an endogenous marker of protein-losing enteropathies]. 143 95

Among 530 consecutive patients hospitalized for acute hepatitis cytomegalovirus infection was diagnosed in 5 (0.9%). In 2 cases the infection was due to blood transfusion. The course of the disease was Got essentially different from hepatitis A, B, or non-A, non-B, however, clinical and biochemical manifestations of cholestasis were common. All biochemical abnormalities returned to normal within few weeks. In conclusion, it seems that cytomegalovirus is a rare cause of clinically overt hepatitis and its course is often cholestatic.
Pol Arch Med Wewn 1991 Jan
PMID:[Cytomegalovirus hepatitis]. 164 69


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