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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

13 children with chronic HBsAg negative hepatitis were examined in this work with the I.F. method. Comparison can be made with a previous work on chronic HBsAg positive hepatitis. 8 of these patients were cases of ECP, 1 was a ECA-A and 4 were ECA-B. Research has been done to point out immunoglobulins and immunocomplexes in the liver and serum. On the whole, fluorescence was less both in liver and serum than fluorescence in chronic HBsAg positive hepatitis. Reasons of it can be: the absence of anti-virus B antibodies (HBcAb, delta-Ab, HBsAb), the relative lightness of our cases and, probably, a better answer of HBsAg negative hepatitis than of HBsAg positive one to immunodepressive treatment.
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PMID:[Chronic HBsAg negative hepatitis in childhood, Stud using the immunofluorescence method]. 703 45

The investigation of hypereosinophilias (HE) is a long and complicated process requiring a close collaboration between biologist and clinician physicians. The latter especially will have to provide information on symptoms (association with a fever; a hepatitis) and on the epidemiological history (patient's occupation and country of origin, and/or time and place of the travels or stays out of the European Union). The first step of laboratory investigations consists of making a check blood count, then measuring the sedimentation rate. At the time of the second step, the measurement of total IgE (a concentration greater than 500 IU/ml is often linked to a helminthiasis), that of specific IgE for common inhalant allergens, and three stool examinations using Baermann's technique will be carried out. The request for parasitic serodiagnoses only will be done if the above-cited investigations are negative, and if HE persists after a therapeutic test. A panel of serological tests often needs to be performed. If a helminthic infection is suspected but the immunodiagnostic methods fail, these tests may be required again after a time of a few weeks. At this stage, the measurement of eosinophil cationic protein is useful, since a high level of eosinophil cationic protein is suggestive of non allergic HE.
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PMID:[Value of laboratory findings in the diagnosis of hypereosinophilia]. 1041 Mar 73

Eosinophils have been associated with the pathophysiology of various allergic diseases and asthma. Eosinophils secrete a number of granule proteins that have been identified as effector molecules responsible for many of the actions of eosinophils. The four major eosinophil granule proteins, major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil derived neurotoxin (EDN) and eosinophil peroxidase have been shown to be involved in a number of eosinophil associated functions. EDN possesses antiviral activity against single stranded RNA viruses like respiratory syncytial virus, Hepatitis and HIV, whereas ECP and MBP have antibacterial and antiparasitic properties. This review summarizes the studies on antipathogenic activities of eosinophil granule proteins against bacteria, viruses, protozoans and helminths.
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PMID:Antimicrobial activity of human eosinophil granule proteins: involvement in host defence against pathogens. 2223 33