Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

two patients with polyarteritis nodosa who presented with vague constitutional systems and hepatitis-B antigenemia are reported. Angiography was used as the primary diagnostic procedure and confirmed the diagnosis in each case. Angiography is a relatively simple and direct means for establishing the diagnosis of polyarteritis nodosa. In these patients, the typical finding of aneurysm formation in multiple organs was observed. Arterial narrowing was also widespread. Multiple renal infarcts are shown in one case, and bronchial arteriography revealed aneurysms and narrowing in bronchial and intercostal arteries in one patient who had a recent pulmonary infarction and a normal pulmonary arteriogram. The relationship of the hepatitis-B antigen and polyarteritis is also emphasized.
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PMID:Polyarteritis nodosa and hepatitis-B surface antigen: role of angiography in diagnosis. 1 66

A parvovirus-like antigen has been found in sera of nine healthy blood-donors and two patients. Its pathogenicity is unknown, but 30% of adults possess specific antibody. The new agent can be confused with hepatitis-B antigen both morphologically and serologically.
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PMID:Parvovirus-like particles in human sera. 4 24

Hepatitis-B antigen (HBsAG) was detected in the sera of 29 or 250 (11.6%) blood donors in Ndola, Zambia, most of whom were prisoners or students. The incidence among prisoners was 15.1%, among students only 1.6%. Thirteen sera were subtyped, nine carried the y and four the d antigenic determinant. Although there was a marked difference in the incidence of HBs antigen between prisoners and students, when donors were tested for antibody to HBsAg (anti-HBs) this positive. Overall, anti-HBs was detected in 132 of 250 blood donors (52.8%). The sensitivity of radioimmunoassay, counter-immunoelectrophoresis and a newly developed passive haemagglutination (PHA) test, employing tanned formalinised antibody coated turkey erythrocytes, was compared. Although radioimmunoassay provided the most sensitive method, the PHA test compared extremely favourably and was considered to be particularly suitable for use in the tropics.
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PMID:The incidence of hepatitis-B-antigen and anti-hepatitis-B among blood donors in Ndola, Zambia. 4 11

Liver biopsies from 18 patients with primary biliary cirrhosis (PBC) and from 25 patients with chronic active hepatitis (CAH) were stained by orcein after oxidation of the tissue sections with potassium permanganate. In 15 out of the 18 cases which could be classified on clinical, biochemical and immunological basis as PBC, the hepatocytes, usually periportally, contained cytoplasmic stainable material. 5 out of the 25 CAH patients contained the same material, but four of these patients were clinically atypical and showed features of cholestatic form of CAH and features crosslinking with PBC. All patients in both groups were serologically hepatitis-B antigen negative. The orcein staining method seems to be a reliable addition to differentiating histologically between PBC and CAH.
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PMID:Orcein positive hepatocellular material in histological diagnosis of primary biliary cirrhosis. 5 54

F-antigen is a liver-specific antigen detected with antibody, raised in allogeneic (CBA) mice, to BALB/c mouse liver extract. The authors have confirmed the hepatic specificity of this antigen by showing it to be absent in extracts of extrahepatic organs of mouse and human origin. It is present in liver extracts of guinea pigs, rats, and rabbits, as well as in liver extracts from mouse and human sources. The antigen was present in the circulation of rabbits with acute carbon tetrachloride-induced hepatocellular injury. It was also demonstrated in the sera of 3 of 8 patients with acute hepatitis B antigen-positive hepatitis and in 1 of 4 patients with chronic active hepatitis. It was absent from the sera of 121 other patients with a variety of hepatic and nonhepatic diseases, and from the sera of 20 healthy subjects. The antigen is immunologically distinct from hepatitis B antigen, from the liver-specific lipoprotein antigen LP-2 of Meyer zum Buschenfeld, and from each of 15 individual human serum proteins tested.
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PMID:F-antigen: nature, liver specificity, and release in experimental liver injury. 5 3

In a four-year prospective study 4000 patients of a gastroenterologic and hematologic department were screened for alpha1-fetoprotein (AFP), lipoprotein-X (LPX), and hepatitis-B antigen and antibody (HBsAg, HBsAb). Only histologically confirmed results were used for the evaluation of this study. Liverscintigraphy using 99m-Tc-S-colloid was performed as the morphological examination. 85% of focal liver diseases were seen as space-occupying lesions in the radioscan. The interpretation of their dignity was performed with success by means of 67-galliumcitrate with an overall diagnostic accuracy of 90%. With the methods, presented in this paper, positive results of AFP-LPX-, HBsAg- and HBsAb-determinations mean, without exception, an informational gain. In 1241 of 4000 patients, 1417 positive results were recorded. In combination with two-step radionuclide-scintigraphy as the morphological element of our screening procedure, focal diseases of the liver are no longer a diagnostic problem. Additional information of diagnostic relevance is expected in about 35% of all diffuse hepatocellular diseases.
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PMID:[Clinical significance of the combined determination of alpha 1 fetoprotein, lipoprotein X, and hepatitis B antigen and antibodies]. 7 18

The results of subtyping the B antigen in 551 sera from patients with viral hepatitis, chronic evolutive hepatitis and cirrhosis, chronic carriers, donors and healthy subjects, were confirmed as positive HBAg by diffusion in agar, counterelectrophoresis and radioimmunology, and characterized by the d-y and w-r determinants by rheophoresis. The high incidence of the y determinant in all nine counties investigated probably reflects the prevalence of this serotype in Romania, recalling the distribution of subtypes observed in the south of Europe.
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PMID:[Distribution of subtypes of viral hepatitis B antigen in areas of Rumania]. 13 42

The observation elsewhere (Drew and Rundle, 1977) that increase frequencies of the C5 + variant of the serum cholinesterase in Down's syndrome may be due to a protective influence against adverse environmental factors has been investigated for such factors as age, sex, duration of institutionalisation, presence of the hepatitis -B antigen and maternal age. With the exception of the maternal age none of the factors tested appear to affect the circulating levels of cholinesterase. A maternal age effect in the Down's subjects was detected with lower levels of the enzyme being found in the subject positive for the C5 + variant born to mothers over thirty-five years when compared to the C5 + subjects born to mothers under thirty-five years. Further studies confirmed the presence of a relationship between maternal age, serum cholinesterase levels and haptoglobin phenotypes.
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PMID:Serum cholinesterase (pseudocholinesterase) in Down's syndrome: 2. Quantitative levels. 14

Postmortem diagnosis of liver cirrhosis was made over a one-year period in 43 cases, 18 of which also exhibited hepatocellular carcinoma. Blood samples taken from these and 120 other patients who died from other diseases were tested for hepatitis-B antigen (HB-Ag) and its antibodies (HB-AB) by counter-electrophoresis. The types of cirrhosis found were classified on the basis of morphological characteristics and available etiological data. The greater part of controls had had cardiovascular diseases and 32 had had non-hepatic carcinoma. Age limits were similar in the cirrhotic and control groups. HB-Ag was detected in 5 of the 25 subjects with macronodular cirrhosis and in one alcoholic patient among 18 subjects with other types of cirrhosis. The possibility of a coincidental HB virus infection existed in the alcoholic case and in one case of macronodular cirrhosis. Only one patient with liver carcinoma had HB-Ag. Among the 120 controls, HB-Ag and HB-AB were found in a one case. Microscopic lesions did not seem to be related specifically to the presence of HB-Ag in the cirrhotic livers.
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PMID:Hepatitis B antigen in liver cirrhosis and hepatocellular carcinoma. 17 69

Long-term treatment with prednisone and azathioprine gives satisfactory results in chronic aggressive (chronic active) hepatitis. Of 18 patients treated between 1966 and 1976 for an average of 2.9 years the disease became inactive clinically, biochemically and histologically in 13; merely two continued to have minimal activity histologically. These patients have not required any treatment for two years (on average). In one patient there are still definite signs of activity and immunosuppressive treatment is being continued. Four patients died of cirrhosis of the liver: two of them had not taken the drugs conscientiously. Death occurred on average two years after the diagnosis had been made. Of the 18 patients five were positive for hepatitis-B antigen.
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PMID:[Long-term results of immunosuppressive treatment of chronic aggressive hepatitis (author's transl)]. 72 Feb 35


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