Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In five children affected by HBsAg positive chronic persistent hepatitis a treatment with Levamisole (LMS) modified several immunological parameters which had been found altered before treatment. In particular the percentage of E rosette forming cells increased while that of EAC decreased; B lymphocytes with SmIgG and the responsiveness to phytohaemagglutinin, which were significantly decreased and increased respectively, got normal values. Since the persistence of HBsAg was unaffected by LMS treatment and a light increase of transaminase serum levels (GPT and GOT) was observed during treatment, doubts are expressed about the opportunity of using LMS in children affected by such a form of hepatitis.
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PMID:[Chronic persistent HBsAg positive hepatitis in children. II. Effect of treatment with levamisole]. 31 Jun 86

E and EAC rosette-forming cells in the peripheral blood and in the liver of subjects with acute and chronic hepatitis were studied. We found a highly significant reduction (P less than 0.01) of E rosette percentage in the lymphocytes isolated from the liver patients with chronic persistent, and chronic active, hepatitis. EAC rosette-forming cells were significantly increased in the liver of patients with chronic active hepatis (P less than 0.01). In this condition lymphocytes with Fc receptor were also found.
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PMID:T and B lymphocytes in the liver and peripheral blood of subjects with acute and chronic hepatitis. 31 35

Some membrane and functional properties of lymphocytes have been examined in a group of children affected with persistent hepatitis. Both absolute and percentage values of B lymphocytes (cells bearing surface Ig) were normal, whereas T lymphocytes (E rosette technique) were decreased in percentage but not as absolute numbers. Only in a close range of mitogen concentration PHA responsiveness was altered, and no modification was found in the percentage of EA and EAC rosettes. A marked increase in lymphocytes lacking both T and B cell markers was observed, which may be related to an increase in precursors of mature cells or to a masking of receptors on the membrane of lymphocytes, but which is probably independent of an increase in the number of K cells, since cells bearing receptors for the Fc fragment were normal.
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PMID:[Increase of the "null cells" in children with persistent hepatitis (author's transl)]. 31 86

The authors report three cases of adult papular acrodermatitis with circulating HBs antigen. The eruption was followed by a benign icteric hepatitis which lasted from 30 to 45 days. In two cases, HBs antigen disappeared in a one month period, in one case the antigen has been present for more than three months. Direct immunofluorescence staining exhibits c3 deposits in the vessels of the dermal lesions, without any deposition of immunoglobulins or fibrinogen. We were unable to demonstrate the presence of HBs and " e " antigens in the skin lesions (using FITC conjugated specific antiserums). Serum protein concentrations of complement components C1q, C4,C3, C3PA were normal as measured by radial immunodiffusion. The percentage of circulating B and T cells was normal, as essayed by E-RFC, EAC-RFC and sIg. Thus, adult papular acrodermatitis, as well as the infantile form, does represent a sign of invasion of a benign viral hepatitis.
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PMID:[Adult papular acrodermatitis (Gianotti's disease). Report of 3 cases]. 86 60