Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An attempt was made to find reliable indices for the early recognition of fatal cases of acute viral hepatitis, using the values of serum proteins with rapid turnover. Prealbumin and alpha2-HS-glycoprotein were measured in the sera of 44 cases by immunodiffusion method before the appearance of hepatic coma and/or gastrointestinal bleeding. The difference of the mean values of prealbumin between fatal and surviving cases of subacute form of fulminant hepatitis was not statistically significant. In contrast to this, there was statistically significant difference between both groups in the mean values of alpha2-HS-glycoprotein (p less than 0.05). The present results indicate the possibility of differentiating fatal cases from surviving ones at an early stage, using the reduction of alpha2-HS-glycoprotein by a simple and reproducible immunodiffusion method.
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PMID:The measurement of serum proteins with rapid turnover for early diagnosis of fatal hepatitis. 9 44

An attempt was made to find reliable indices for early diagnosis of fatal cases of acute viral hepatitis, using the values of serum proteins with rapid turnover. Of the subfractions of serum protein, prealbumin, alpha2-HS-glycoprotein and Normotest were measured simultaneously before the appearance of hepatic coma/or gastrointestinal bleeding in 78 cases of acute viral hepatitis, verified by biopsy or necropsy. The mean value of prealbumin with a very short half-life of one or two days, was 6.0 mg/dl in fatal cases, 7.4 mg/dl in surviving ones of subacute form of fulminant hepatitis. The difference between fatal and surviving cases was not statistically significant. In contrast to this, the values alpha2-HS-glycoprotein with a comparatively short halflife of four to six days, showed statistically significant difference between fatal (21.9 mg/dl) and surviving cases (37.4 mg/dl). Normotest was also depressed in fatal (10.7%) and surviving cases (45.3%). The difference was statistically significant. The present results indicate the possibility of differentiating fatal cases from surviving ones at an early stage, using the reduction of alpha2-HS-glycoprotein and the value of Normotest.
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PMID:Rapid turnover serum proteins in fulminant hepatitis. 60 67

In 104 patients with acute virus hepatitis, chronic hepatitides, cirrhoses, fatty livers and biliary diseases with partial and complete obstructive jaundice, respectively, IgG, IgA, IgD, beta1A- and beta1E-globulin, cholinesterase, total protein, and albumin, in 45 of these patients additionally prealbumin, retinol binding protein, thymol turbidity test were determined as well as an electrophoretic separation of the serum was performed. 11 persons with healthy liver served as control group. According to the results of univariate and multivariate variance analyses with following test of redundance (test for indispensability) and analysis of discriminance with calculations of reclassification IgD, beta1E-globulin and retinol binding protein were identified as not evident or redundant. Electrophoresis and thymol turbidity test give sufficient basis informations and can further be recommended for orienting examinations. Immune globulinogrammes from IgB, IgA and IgM are suitable as so-called mesenchyma tests particularly for controls of the course. Prealbumin and cholinesterase prove to be the most sensitive parameter of synthesis, whereas albumin and beta1A-globulin possess a high prognostic evidence.
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PMID:[Discriminatory function of serum proteins in liver and biliary tract diseases]. 91 May 27

We investigated the serum prealbumin by the immuno-diffusion method quantitatively according to the method of Manzini in 20 normal persons, 30 patients with hepatitis virosa acuta, 24 patients with hepatitis chronica and 11 patients with cirrhosis of the liver. The serum prealbumin was significantly decreased in patients with hepatitis acuta virosa, hepatitis chronica aggressiva and in cirrhosis of the liver, but in the patients with the hepatitis chronica persistens the serum prealbumin levels were normal or little increased. According to our results we concluded that the determination of serum prealbumin is important only for the differential diagnosis between the hepatitis chronica aggressiva and hepatitis chronica persistens. However these determinations are not of values in the differential diagnosis between hepatitis chronica aggressiva and cirrhosis of the liver.
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PMID:[The serum prealbumin significance in differential diagnosis of the liver diseases (author's transl)]. 125 37

In 25 patients with chronic renal failure, treated with haemodialysis (13 patients with chronic non-A, non-B hepatitis, and 12 cases without evidence of hepatocellular damage), and in 20 healthy persons, blood serum concentrations were determined of prealbumin, ceruloplasmin, alpha 2-macroglobulin, and haptoglobin. It was found that the concentrations of these proteins in both subgroups of patients were not significantly different. The concentration of prealbumin was higher, and that of alpha 2-macroglobulin and haptoglobin was significantly lower in comparison with healthy subjects.
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PMID:[Concentration of prealbumin, ceruloplasmin, alpha-macroglobulin and haptoglobin in blood serum of patients with chronic non-A, non-B hepatitis treated with hemodialysis for chronic renal failure]. 128 60

A radioimmunoassay for human plasma retinol-binding protein (RBP) has been developed utilizing a double antibody precipitation technique. RBP was purified 1500- to 2000-fold by procedures described previously. A specific anti-human RBP antiserum was prepared in rabbits by three once-weekly injections of purified RBP emulsified with Freund's adjuvant. RBP was iodinated with (131)I and the RBP-(131)I was purified by gel filtration on Sephadex G-100 after complex formation with human plasma prealbumin. The RBP-(131)I was completely (> 95%) immunoprecipitable in the presence of an excess of specific antiserum, it was not (< 5%) immunoprecipitable in the absence of specific antiserum, and it could be completely displaced from antibody by excess unlabeled RBP. The standard curve obtained in the immunoassay with normal plasma was identical to that with pure RBP. Duplicate samples differed from their mean by 5 +/-5% (+/-SD). There was a quantitative recovery of pure RBP added in varying amounts to normal plasma. The immunoassay accurately measured RBP in amounts of 10-100 ng per assay tube. There was no significant difference in the immunoreactivity of apo-RBP as compared to holo-RBP. The mean plasma values (+/-SEM) for a group of 76 normal subjects were 47.2 +/-1.6 mug/ml for males and 41.6 +/-1.6 mug/ml for females. Plasma RBP levels were markedly depressed (15 +/-2.3 mug/ml) in 14 patients with acute viral hepatitis. There was a highly significant correlation between the plasma levels of RBP and of vitamin A in both normal subjects and patients with hepatitis. In all subjects plasma RBP was generally saturated with retinol. The data suggest that under normal circumstances RBP circulates almost exclusively as the holoprotein.
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PMID:Radioimmunoassay of human plasma retinol-binding protein. 498 83

Acute-phase proteins (APRs), albumin, and alpha 2-macroglobulin (alpha 2M), were studied in 14 patients with acute hepatitis B. No acute-phase reaction in this disease was observed, contrary to other viral infections. Peak SGPT correlated negatively with prealbumin, but no other relations with APR, albumin, or alpha 2M were found. As many APRs have antiinflammatory properties, the relation of these proteins at the start and the subsequent course of hepatitis, measured by "SGPT area" and duration of the illness, was calculated. The serum level of APR and albumin at the start of the disease is not significantly related to the subsequent course. However alpha 2M, not being an APR, and prealbumin are negatively correlated to these parameters: high levels of alpha 2M and prealbumin point to a less severe course than low levels. The clinical significance of the depressed acute-phase reaction during hepatitis and the effect of alpha 2M are discussed.
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PMID:Profiles of acute-phase reactants and clinical significance of alpha 2-macroglobulin in acute hepatitis B. 608 4

We have been determining the GGT IE isoenzyme in patients with hepatitis A and B with decomposed liver cirrhosis, with obstructive hepatitis caused by the gall stones. In patients with hepatitis A and B the IE is located between albumin and betaglobulin, as well as in patients with obstructive hepatitis caused by the gall stones; in the latter partly between Alpha 1 and Alpha 2 globulin. In patients with decompensated liver cirrhosis (37.7% of the patients) there was IE activity 100% in Alpha 2 globulin area; in 6.25% of patients the activity was in the prealbumin area. In patients with secondary liver tumors we got a rather high increase of the GGT IE activity in Alpha 1 globulin area, in 77.7% of the patients even 80 to 100%. In some patients with disease progression we noticed the GGT IE activity in Beta globulin area. The results in primary liver malignomas were different. In 68.5% of the patients the GGT IE activity dominated in Alpha 1 globulin area.
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PMID:[Isoenzymes of gammaglutamyltransferase in patients with obstructive and hepatocellular icterus]. 1054 25

<i>Background:</i> Patient immune response is one of the main factors influencing hepatitis virus (HBV) eradication or chronicity. Our study aimed to investigate the relationship between the nutritional status and immune function, and to provide the appropriate clinical diagnosis data for treatment of patients with chronic hepatitis B virus (CHB) and cirrhosis. <i>Methods:</i> T lymphocyte subsets were tested using flow cytometry in 100 patients (48 with CHB, 52 with cirrhosis) and 26 healthy individuals. Nutritional parameters were analyzed including body mass index (BMI), blood white blood cell count, albumin, prealbumin, and biochemistry parameters in patient and control groups. <i>Results:</i> Moderate and severe malnutrition (53.84%) were observed in HBV-cirrhosis patients. Serum albumin and prealbumin levels were the lowest in the cirrhosis group. There were significantly lower levels of lymphocyte subsets (CD3+, CD3+CD4+, and CD3+CD8+) in patient groups compared with the control group. There was significantly lower cholesterol, white blood cells, lymphocytes, and platelet levels in the patient group compared with the control group. Interrelation between nutritional and immune parameters showed that serum prealbumin levels were negatively correlated with CD3+, CD3+CD4+, and CD3+CD8+ count in the CHB group, and the immune parameters (CD3+, CD3+CD4+, and CD3+CD8+ count) correlated significantly with BMI in the patients with cirrhosis (r > 0.45). <i>Conclusions:</i> Our data demonstrate that there is a correlation between nutrition deficiency and immune dysfunction in patients with CHB and cirrhosis. It is necessary to assess the nutritional status and immune balance in these patients.
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PMID:Changes in Prealbumin and Body Mass Index Associated with T Lymphocyte Subsets and Nutritional Status in Chronic Hepatitis B and HBV-Cirrhosis Patients. 3054 85