Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hepatitis C virus (HCV) infection related hepatitis remains one of the most serious health problems world-wide. During investigation of hypervariable region 1 (HVR1) of HCV, a seven amino acids mimic peptide (GQTYTSG, named 7-P) was identified within the N-terminal of HVR1 that could protect porcine serum (PS)-induced hepatic injury in rats. 7-P could not only decrease the serum levels of aminotransferases (ALT, AST), alkaline phosphatase (AKP), and billirubin, but were also effective in reversing histopathological evidence of PS-induced rat chronic liver injury. The protective mechanism was investigated in detail using Affymetrix microarrays analysis. The bioinformatic data was confirmed by western blotting. Further studies revealed that IL-1beta, tumor necrosis factor receptor superfamily 14 (TNFRSF14), intercellular adhesion molecule 2 (ICAM2), sterol regulatory element-binding protein 1 (SREBP 1), Prohibitin (PHB), and inhibitor of DNA binding 2 (Id2) were the key factors for 7-P-induced hepatoprotective effect. Together these data suggest that 7-P mimic from HVR1 of HCV protects hepatic injury by reducing the expression of key pro-inflammatory factors. 7-P might have potential therapeutic application for hepatitis in human beings.
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PMID:7-aa peptide mimic from HVR1 of HCV protects hepatic injury in rats by reduced expression of key pro-inflammatory factors. 2040 48

Prohibitin (PHB) 1 is involved in multiple regulatory pathways in liver disease to protect hepatocytes, and its function is associated with subcellular localization. PHB1 located in the nucleus, cytoplasm and the mitochondrial inner membrane has anti-oxidative stress and anti-inflammatory effects in hepatitis and cirrhosis, which can protect liver cells from damage caused by inflammatory factors and reactive oxygen species (ROS) stimulation. The low expression of PHB1 located in the nucleus of liver cancer cells inhibits the proliferation and metastasis of liver cancer; thus, PHB1 exhibits the function of a tumor suppressor gene. Understanding the mechanisms of PHB1 in liver diseases may be useful for further research on the disease and may provide new ideas for the development of targeted therapeutic drugs in the future. Therefore, this review puts forward an overview of the role of PHB1 and its protective mechanism in liver diseases.
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PMID:Can Prohibitin 1 be a Safeguard against liver disease? 3155 19