Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute hepatitis induced by heliotrine is accompanied by uncoupling of oxidative phosphorylation in liver mitochondria. The rate of oxygen uptake during succinate oxidation increased in all metabolic states, while the respiratory control index decreased by 45% because of the greater increase in the respiration rate in state 4 by comparison with that in state 3. Heliotrine poisoning also halved the rate of oxygen uptake in rat liver homogenates in the presence of ascorbate and tetramethylene-p-phenylenediamine. This is indicative of a lowering of cytochrome oxidase activity and of energy metabolism disturbances in rat liver. Preparations of cotton phosphatidylcholine (PC), both purified and as ATP-containing complexes (PC+ATP), as well as ATP alone, reduced the metabolic disorders in liver mitochondria of rats with acute heliotrine-induced hepatitis. The therapeutic effect of these preparations consisted in the restoration of oxidative phosphorylation coupling and of the cytochrome oxidase activity. The effect of PC+ATP was much greater than either PC or ATP alone. In contrast, the commercial preparation, Essential, had no beneficial effect.
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PMID:Disturbances in oxidative phosphorylation in the liver of rats with heliotrine-induced hepatitis and restoration by phosphatidylcholine and ATP. 166 44

The purpose of the given research work was to study the features of morphologic changes arising during the treatment of chronic hepatitis with NEOSELEN. Chronic active hepatitis was set up in laboratory rats, post-forming in chronic persisting hepatitis and its transformation in a certain part of animals into cirrhosis by administration of HELIOTRINE over the period of 40 days. Morphologically hepatic cirrhosis was small nodular. NEOSELEN was found to have a good therapeutic effect in treatment of chronic hepatitis as we have seen noticeable remittance of destructive necrotic changes in hepatic parenchymatouse elements and reduction in a volume of proliferative inflammatory infiltration along with acceleration of fibrosis process only in periportal zones of hepatic lobules. The therapeutic efficacy of NEOSELEN prevents transmission of chronic hepatitis into cirrhosis in a greater part of animals thus giving morphologic signs of importance of NEOSELEN in a restorative process of destructive and inflammatory changes in the affected liver.
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PMID:[Morphological characteristics of chronic toxic hepatitis treated with neoselen]. 1496 10