Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Antioxidative effect of phospholipid complex from the sea organisms (preparation "Kalmofil") is observed comparatively with other phospholipid fractions of animal and plant origin. Most antioxidative action of the phospholipid complex from Mollusca (preparation "Kalmofil") on the nonenzymatic LPO reactions in vitro is established. Analogous fractions from different functional animal tissues have not such influence. Application of "Kalmofil" in vivo under experimental rat hepatitis provoked by CCl4 has a corrective effect on both nonenzymatic and Fe(2+)- and NADP.H-depending LPO reactions. This preparation decreases toxic influence of CCl4 and improves antioxidative system of rat hepatocytes.
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PMID:[Antioxidant effect of a phospholipid complex isolated from marine organisms]. 787 94

The aim of the present study is to carry out a clinical-statistical research into a large number of patients suffering from oral lichen planus (LPO) and from different odontostomatologic pathologies. In both groups of patients serum transaminase values and eventual presence of hepatopathy viral markers were investigated in order to identify a possible correlation between the aforesaid parameters and LPO, considered in its various clinical forms (papular and erosive essentially). Results had showed a close association between hepatopathy and LPO, according to results of studies performed by other Italian and Spanish groups and differently from Anglo-Saxon authors: above all an increased incidence of C hepatitis in patients with lichen was observed. Furthermore our investigation is agreed in underlining the great importance to attach to erosive form of oral lichen, that seems to join to active chronic hepatitis most frequently than papular one.
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PMID:[A statistical epidemiological study of a possible correlation between serum transaminase levels and viral hepatic pathology markers and lichen planus orale]. 917 26

It has been shown in experiments on Wistar rats that the antitumor agent platidiam given in MTD causes increased activity of alanine and aspartate aminotransferases (up to the 15th day after administration), persisting changes in the beta- and pre-beta-lipoprotein level, and intensified LPO in the blood (up to 3-months). Acute toxic hepatitis induced in rats by injection of CCl4 1, 3, and 6 months after a single platidiam administration is characterized by hepatic disorders which are more pronounced than those than those in intact animals with CCl4 hepatitis.
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PMID:[The early and late sequelae of the toxic action on the liver of a platinum antitumor preparation]. 937 61

Using rat model of chronic toxic hepatitis we showed the involvement of the lymph system in the formation of the response to toxic liver damage consisting in deposition of LPO products in the central lymph and active involvement of antioxidants in their neutralization with redistribution of ceruloplasmin into lymph vessels against the background of reduced a-tocopherol content in the central lymph.
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PMID:Pro- and antioxidants in the central lymph in experimental chronic toxic hepatitis. 1952 92

Analysis of the effects of retinol acetate on LPO processes in vivo revealed antioxidant effects under normal conditions and during experimental free-radical pathology (toxic hepatosis-hepatitis). The concentration inversion of antioxidant effects of retinol acetate into prooxidant effects were observed only under normal conditions.
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PMID:In vivo analysis of antioxidant and prooxidant properties of retinol acetate. 2431 53