Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the present paper the effect of the pretreatment with epsilon-amino-trimethyllysine (TML) 10 mg/kg on the DGA-induced hepatitis in mice is described. TML-pretreatment was chosen because experiments indicated that TML treatment elicits processes in the liver similar to that occurring during regeneration on one hand, on the other hand because it was shown that DGA proved to be ineffective in newborn or in partially hepatectomized animals, that is to say on regenerating liver. It was expected that TML pretreatment would protect the animals against the hepatitis inducing effect of DGA. Unexpectedly pretreatment with TML had just the opposite effect, resulting in a severe hemorrhagic hepatitis in several animals. Biochemical and morphological studies are in progress to elucidate the mechanism of this peculiar effect.
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PMID:Light and electron microscopic study of hermorrhagic hepatitis induced by trimethyllysine and D-galactosamine. 91 31

Employing high-performance liquid chromatography with isocratic elution using a two-column system (mu Bondapak C18 and mu Bondapak CN) and phenyl isothiocyanate as a fluorogenic reagent, NG-monomethylarginine (MMA). NG-dimethylarginines, and epsilon-N-trimethyllysine (TML) can be quatitatively separated from human serum samples. The recoveries of these amino acids were over 90%. It was observed that the serum concentrations of MMA, DMA and TML were significantly elevated in sera obtained from patients suffering from diabetes mellitus, hepatitis or hyperthyroidism, particularly the last condition.
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PMID:Determination of methylated amino acids in human serum by high-performance liquid chromatography. 313 87