Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Screening for hepatitis Bs antigen in late pregnancy was introduced in mid-1983 at the University Women's Hospital, Berne. 4118 pregnant women had been investigated by the end of 1986, of whom 26 (0.63%) turned out to be HBsAg positive. The prevalence of HBsAg carriers was 0.12% in Swiss women, 0.65% in other European women, 12.5% in women from the Far East and 5.6% and 4.9% in women from the Near East and Africa respectively. Newborns of HBsAg positive mothers simultaneously received hepatitis B immunoglobulin (400 IU anti-HBs) and a first injection of hepatitis B vaccine (Hevac B 5 mg) in the first hours of life, followed by vaccinations after two, three and twelve months. Of 18 children investigated after the first year of life none was HBsAg positive. 14 children (78%) were shown to have HBs antibodies. Two of the four anti-HBs-negative unfortunately received only the first vaccine injection after birth. Taking this fact into account, the "success rate" of the immunoprophylaxis is 88%.
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PMID:[Hepatitis B screening in late pregnancy and results of immunization in newborn infants]. 296 28

Among the large spectrum of pharmacological activities of flavonoids, play an important role the recently investigated properties involving the arachidonic acid metabolism. In order to clarify the mechanisms of "cytoprotection" of the 3-palmitoyl-(+)-catechin (Palm-cat), a new flavonoid compound (C31 H44 O7) we have studied in experimental hepatitis of the rat, induced by Galactosamine (Ga1N) and E. coli 055:B 5 endotoxin (LPS), hepatic cAMP and cGMP, transaminases, bilirubin and endotoxemia. The Palm-cat significantly increases cyclic-GMP levels in the liver, whereas reduces or slightly modifies the cAMP. Transaminases and bilirubin values increase both in controls and flavonoid treated rats. The flavonoid significantly decreases the frequency of endotoxemia. These effects suggest that RES and hepatocytes functions, immune and inflammatory response can be affected in liver disease by flavonoids via cyclic nucleotides regulation.
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PMID:Flavonoids and hepatic cyclic monophosphates in liver injury. 608 50

The effect of segmental transcatheter arterial chemoembolization (TAE) on serum amino acid levels and liver function were studied in 23 patients with HCC associated with hepatitis virus C (22 patients) or alcoholism (1 patient), with compensated liver cirrhosis (Child A 18 patients, Child B 5 patients). Serum levels of branched-chain amino acids (BCAA), tyrosine, branched-chain amino acids to tyrosine ratio (BTR), ammonia, total bilirubin and albumin, and prothrombin times were measured before and after TAE (24 h, 7 and 14 days). The BTR was increased significantly 24 h after TAE (p<0.001) and gradually decreased to pre-TAE levels. Serum tyrosine levels decreased at 24 h after TAE (p<0.005) and later increased. Serum BCAA levels increased slightly at 7days after TAE and were decreased at 14 days after TAE. This results indicated that the increased BTR was due primarily to the decreased tyrosine level at 24 h after TAE. Serum ammonia levels gradually decreased after TAE and the prothrombin time and serum levels of total bilirubin and albumin were not significantly changed. In this study, segmental TAE had little influence on liver function, and the BTR unexpectedly increased at 24 h after TAE. These results suggest that segmental TAE has minimal side effects and may have a beneficial effect on amino acid metabolism.
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PMID:Effect of segmental transcatheter arterial chemoembolization on branched chain amino acids and tyrosine ratio in patients with hepatocellular carcinoma. 1102 1