Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Overall 180 children aged 3 months to 12 years with acute and chronic hepatitis B and delta were examined for macrophagal function. Chemotaxis, saturation with esterase, the content of nuclear RNA were estimated, antigens of HB virus in these cells were identified as well. The data obtained attest to the correlation between the degree of macrophagal function disorders and the gravity of acute virus hepatitis. The chronic disease is characterized by stable depression of mononuclear cells with a tendency toward deeper depression of their function in patients with virus hepatitis delta as well as a higher rate of HBsAg and HBeAg demonstration in these cells. The authors provide evidence for advisability of the use of BCG vaccine and tactivin in patients with the chronic disease, since they improve macrophagal function, promote the inhibition of HB-virus replication and the onset of a stable remission in patients with chronic hepatitis B and delta.
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PMID:[The pathogenetic significance of disorders in macrophage function in viral hepatitis B and delta in children]. 147 35

The disposable unit-dose BCG vaccine for multipuncture has some advantages in that the vaccination can be performed immediately without arrangements even by laymen, anytime, anywhere when needed, with no chance of contamination as hepatitis infection. No decrease of potency at vaccination, and no wastage of vaccine was observed. This vaccine showed the stability of potency the same as multi-dose vaccine. The tuberculin conversion rates and local lesions induced by this vaccine on babies and infants were observed to be the same as the multi-dose vaccine.
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PMID:Disposable unit-dose BCG vaccine for multi-puncture vaccination. 359 25

In the treatment of HBs-Ag positive, chronic aggressive hepatitis three therapeutic methods can principally be applied: immunosuppression, immunostimulation and an attempt at medicamentous inhibition of the virus propagation. According to the present view, the immunosuppressive treatment with glucocorticoids and azathioprine is very risky in the antigen positive form and doubtful as far as the application is concerned; it simply suppresses the defensive reaction of the organism, thus encouraging the virus replication. In individual cases remissions could be achieved by immuno-stimulation with BCG vaccine or cell wall preparations of the Propionibacterium granulosum, or by an abrupt discontinuation of an immunosuppression. Neither has the virostatic treatment with vidarabin and its monophosphatester , which was introduced in the last few years, brought any new breakthroughs. Under treatment it is mostly possible to block the virus propagation, however, after discontinuation relapses are usually the rule and lasting therapeutic successes the exception to the rule.
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PMID:[HBs-antigen-positive chronic aggressive hepatitis]. 620 11

The results of nonspecific immunotherapy with BCG vaccine in 98 cases of melanoma, breast cancer and other malignancies were used in evaluating the frequency and degree of side-effects and complications arising in cancer patients during this treatment. The procedure proved to be safe irrespective of patients' age. Prevention and treatment of side-effects such as fever, water-salt disorders, anorexia, interstitial hepatitis and promotion of tumor growth are discussed.
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PMID:[Treatment of the complications occurring in BCG vaccine immunotherapy of patients with malignant neoplasms]. 646 96

Bacillus Calmette-Guerin (BCG) therapy has been proven to be effective treatment for superficial bladder carcinoma with complications that are usually minor and self limited. Although rare, granulomatous hepatitis can develop, and it is important to recognize it and treat it promptly. The hepatitis which occurs appears to be the result of a hypersensitivity reaction to antigens present in the BCG vaccine. Pathological findings include hepatocellular necrosis and pleomorphism, microgranulomas and non-caseous epitheliod granulomas with giant cells. A case of BCG-hepatitis, which developed in a 74-year-old white male following immunotherapy for superficial bladder carcinoma, is described.
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PMID:Granulomatous hepatitis as a complication of intravesical Bacillus Calmette-Guerin therapy for bladder carcinoma. 748 16

The development of granulomatous lesions in distant organs is an uncommon complication of the immunotherapy with BCG vaccine. We report a case of granulomatous hepatitis after the 12th BCG intravesical instillation (6 weekly followed by 6 monthly) in a 58-year-old man with superficial bladder cancer. The patient was admitted because of fever and jaundice. Disseminated BCG infection was suspected on the basis of history, clinical examination and a liver biopsy that showed noncaseating granulomatous hepatitis. PCR for M. bovis was positive in the liver tissue, confirming the mycobacterial dissemination. Our patient improved clinically with a regimen including both corticosteroids and antituberculosis agents.
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PMID:BCG-related granulomatous hepatitis. 1749 Dec 6