Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Since 1971 pyrimethamine-sulfadoxine (Fansidar, Roche) has been used worldwide for prophylaxis and therapy of chloroquine resistant Plasmodium falciparum malaria. The drug monitoring team of the producing firm has received reports of a number of cutaneous adverse reactions, some severe, and a few even with fatal outcome. Liver reactions were also encountered, with severe cases only in the recent literature. We report on two patients with hepatitis in temporal relationship to pyrimethamine-sulfadoxine, the first with a second event after later exposure to the same drug. After discontinuing the medication the liver function abnormalities returned to normal limits within a few weeks. Liver biopsy and a positive lymphocyte transformation test against sulfadoxine, a component of Fansidar, strongly suggest that Fansidar was the cause of hepatic injury.
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PMID:[Acute hepatitis following administration of fansidar]. 230 11

We report on a 27-year-old patient with recurrent cholestatic hepatitis in whom the symptoms developed each time after travelling in tropical areas. Our primary diagnosis was recurrent non-A-non-B-hepatitis after exclusion of other forms of infectious hepatitis, but careful exploration identified Fansidar as the causative agent of liver damage.
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PMID:[Drug-induced hepatitis caused by Fansidar]. 311 58