Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

For investigation of the specificity of leukocyte hepatitis virus (LHV) in Botkin's disease, 369 patients with virus hepatitis, 96 donors and 61 patients with acute respiratory diseases were examined. The occurrence of specific antibody to LHV was determined by a micromodification of the conventional CFT. LHV was passaged in leukocyte culture stimulated with phytohemagglutinin. A control antigen was a leukocyte culture from the same donor not infected with LHV. An additional control was Epstein-Barr virus passaged in continuous leukocyte suspension cultures. The complement-fixing antibody to LHV was detected in sera from children and adults with virus hepatitis. The number of sera with antibody to LHV was significantly higher than that in the control groups. A rise of antibody titers in the course of the disease in the experimental groups in contrast to the controls attested to certain specificity of LHV in Botkin's disease. No antigenic relationship between LHV and HB antigen was found in serologic tests. The lack of differences in detection of the complement-fixing antibody to Epstein-Barr virus in the experimental and control groups suggests no role of this virus in the etiopathogenesis of Botkin's virus hepatitis.
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PMID:[Serological study of the specificity of leukocyte hepatitis virus]. 125 59

The 170 prostitutes registered by the local public health authority (165 female, 5 male; ages 17-61) were serologically investigated by ELISA and CFT for the presence of hepatitis B virus (HBV) markers (n = 170), anti-CMV (n = 118) and anti-HSV 2 antibodies (n = 117). 4.7% (1.2%) were found to be HBs- (HBe-)antigen carriers; 1.2% revealed an acute hepatitis B (seroconversion of anti-HBc or IgM-anti-HBc highly positive); 17.1% presented a past and resolved hepatitis B (anti-HBs positive). These rates exceeded those of 125 female age-matched control persons considerably, out of whom only 2.4% (0.8%) presented HBs-(HBe-) antigen and 3.2% anti-HBs antibodies. 90% of the prostitutes investigated proved to be anti-CMV IgG (1.7% IgM) antibody positive and were compared to healthy blood donors (47% IgG, 0% IgM-anti-CMV antibody carriers) and other CMV risk groups: pregnant women 56 (13), patients in hemodialysis 61 (0), hemophiliac patients 69 (0), patients after kidney transplantation 90 (16) and after open-heart surgery 87 (4) % anti-CMV IgG (IgM) antibody carriers. An AIDS patient suffered from simultaneous HBV and CMV infections. The risk of HSV 2 infection is among prostitutes (38.5% seropositives) five times as high as among female age-matched control persons (7.2% seropositives, n = 125). These results confirm that prostitutes must be regarded as a risk for the spread of hepatitis BV and CMV- and HSV 2-caused diseases in the population.
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PMID:Incidences of antibodies to hepatitis B, herpes simplex and cytomegalovirus in prostitutes. 299 Jan 24