Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A clinically characteristic hypersensitivity reaction to phenytoin occurred in two patients three to four weeks after they started phenytoin therapy. It consisted of a characteristic rash, fever, tender generalized lymphadenopathy, leukocytosis with atypical lymphocytes, and eosinophilia. One patient had liver function abnormalities suggestive of hepatitis, as have most previously reported cases. The rash was pruritic and generalized; it consisted of irregular, ill-defined macular erythema in patches with superimposed follicular papules and massive edema of the face and periorbital region. Facial edema is characteristic of this syndrome. In one case the rash progressed to include follicular pustules and resolved with superficial desquamation. Histopathologic specimens from both cases showed a dense, superficial lymphohistiocytic infiltrate in the dermis and epidermal spongiosis. Intraepidermal pustules were present in one patient. The importance of recognizing this syndrome is stressed because it is potentially fatal.
Arch Dermatol 1978 Sep
PMID:Phenytoin hypersensitivity reaction. 15 Aug 18

The authors report a case of diffuse scleroderma in a 15 months old infant. Dermatologic (clinical and pathological) findings are quite typical of the disease. On the other hand, in this case some particularities were observed: the age of the infant (second published case beginning before the age of two); the presence of a durable eosinophilia, the absence of visceral lesions and of biological abnormaliteis (of auto-immune nature specially), the evolution towards athrepsica and death within one year. Thus, because of these particularities, the diagnosis of scleroderma remains questionable and the diagnosis of progeria has been considered. The affection appeared in the course of a hepatitis leaving a hepatic fibrosis without inflammatory signs; no conclusion can be drawn about the relations between the hepatic affection and the fatal dermatologic disease.
Ann Dermatol Venereol 1977 Nov
PMID:[An case of acute diffuse seleroderma in an infant]. 61 54

A case of papular acrodermatitis (PAC) associated with acute anicteric type B hepatitis occurred in a 2-year-old child. Immunocytochemical studies failed to detect the presence of viral antigens in the involved skin lesion. Current knowledge of the hepatitis B viral antigens and of their possible role in PAC is discussed.
Arch Dermatol 1978 Oct
PMID:Papular acrodermatitis of childhood and hepatitis B infection. 71 95

The authors report three cases of adult papular acrodermatitis with circulating HBs antigen. The eruption was followed by a benign icteric hepatitis which lasted from 30 to 45 days. In two cases, HBs antigen disappeared in a one month period, in one case the antigen has been present for more than three months. Direct immunofluorescence staining exhibits c3 deposits in the vessels of the dermal lesions, without any deposition of immunoglobulins or fibrinogen. We were unable to demonstrate the presence of HBs and " e " antigens in the skin lesions (using FITC conjugated specific antiserums). Serum protein concentrations of complement components C1q, C4,C3, C3PA were normal as measured by radial immunodiffusion. The percentage of circulating B and T cells was normal, as essayed by E-RFC, EAC-RFC and sIg. Thus, adult papular acrodermatitis, as well as the infantile form, does represent a sign of invasion of a benign viral hepatitis.
Ann Dermatol Venereol 1977 Mar
PMID:[Adult papular acrodermatitis (Gianotti's disease). Report of 3 cases]. 86 60

A 28-year-old man who had suffered from erythropoietic protoporphyria since infancy was referred because of worsening photosensitivity. Conventional therapy with beta-carotene, terfenadine and topical sunscreens was ineffective or not tolerated, and he was treated with transfusions of washed packed cells. Unexpectedly, his photosensitivity deteriorated further, his whole blood protoporphyrin levels doubled and he developed abnormal liver function tests. This is the first report of such an adverse response to blood transfusion therapy for erythropoietic protoporphyria and may have been related to subclinical hepatitis or the increased iron load associated with blood transfusion.
Br J Dermatol 1992 Nov
PMID:Erythropoietic protoporphyria, transfusion therapy and liver disease. 146 96

An 11-year-old boy had lentil-sized lichenoid papules, localized to the limbs and trunk, together with acute, nonicteric, hepatitis B surface antigen-positive hepatitis. The clinical picture and course were typical of Gianotti-Crosti disease. Monoclonal antibodies were used to study the lymphocyte subpopulations and surface antigens in the inflammatory infiltrate in frozen sections of a skin biopsy specimen. The results provide data on the pathogenic mechanism of the papular exanthem.
Pediatr Dermatol 1991 Sep
PMID:Papular acrodermatitis of childhood (Gianotti-Crosti disease). 174 33

A periodic eruption of porokeratosis developed in a 31-year-old black woman with chronic idiopathic hepatitis requiring liver transplantation. The clinicopathologic features were chiefly those of linear and punctate porokeratosis but overlapped those of porokeratosis plantaris, palmaris et disseminata and hyperkeratotic or verrucous porokeratosis. Typical cornoid lamellae were visible on histologic examination. Outbreaks of the lesions occurred during exacerbations of the liver disease. The skin condition rapidly improved after operation, with concomitant improvement in liver function.
J Am Acad Dermatol 1991 Nov
PMID:Linear and punctate porokeratosis associated with end-stage liver disease. 176 74

The most serious side effect of ketoconazole is hepatitis, which has proved fatal in seven reported cases. We present a case of fulminant hepatic failure in a 45-year-old Oriental woman that probably would have been fatal except for a successful liver transplant. A review of the literature of fatalities associated with ketoconazole is presented.
J Am Acad Dermatol 1991 Aug
PMID:Ketoconazole-induced fulminant hepatitis necessitating liver transplantation. 153 78

In a retrospective study of 421 patients infected with human immunodeficiency virus, 15 (3.5%) had varicella. Twelve patients had a typical varicella. Complications were as follows: profuse eruption, 6; hemorrhagic eruption, 1; hepatitis, 5; and pulmonary involvement, 1; 1 patient developed an intravascular disseminated coagulation and died of varicella. Three patients with acquired immunodeficiency syndrome, having a history of varicella, presented with an atypical form of varicella with a small number of disseminated cutaneous poxlike lesions; 1 of these patients experienced three relapses of atypical varicella. Assay of serum antibodies to varicella zoster virus showed that, while typical varicella was the primary varicella zoster virus infection, atypical varicella was a reactivation of varicella zoster virus infection. Acyclovir was given to 11 patients and vidarabine to 1 patient. The one patient who died and the one who suffered a relapse had received acyclovir. Thus, varicella in patients infected with human immunodeficiency virus may be complicated and even lethal. Atypical forms of varicella could be, as is the case with herpes zoster, a reactivation of endogenous varicella zoster virus.
Arch Dermatol 1990 Aug
PMID:Varicella in patients infected with the human immunodeficiency virus. 220 Mar 49

In this study the data on 200 patients affected by various features of lichen planus (LP) are reported. All subjects were in-patients of the Department of Dermatology, Bari, from 1973 to 1988. In 87% of cases the disease appeared as lichen tuber planus, and in 9% there was involvement of mucous membranes. Equal involvement of sex incidence has been found, and the patients were middle-aged (mean, 47 years). The lesion were not subsided in about 10% of cases. Associated fortuitous skin conditions were mainly alopecia areata and vitiligo. In addition, LP has been observed in association with diabetes (8%) and hepatic diseases (10%). These last values could appear relevant, but in our region, Apulia, both diabetes and hepatitis, and especially B-hepatitis, are very frequent diseases. Our clinical follow-up did not allow to consider LP as a symptom of other subsequent organic diseases.
G Ital Dermatol Venereol 1990 Mar
PMID:[A retrospective study of 200 cases of lichen]. 237 21


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