Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Blood substitute products for the treatment of hemorrhagic shock are discussed with regard to their composition, physical and therapeutic characteristics, adverse effects, cost, and market availability. Commercially available plasma expanders discussed include blood derivatives (whole blood, packed red blood cells, plasma, normal human serum albumin, and plasma protein fraction), synthetic colloids (dextrans 40 and 70) and a balanced salt solution (lactated Ringer's injection). Plasma substitutes alone are administered until the hematocrit falls below 30% of coagulation difficulties develop. Normal serum albumin 5% and plasma protein fraction 5% are excellent colloidal plasma expanders without the potential hazard of hepatitis. Lactated Ringer's injection is the fluid of choice to replace lost blood up to 10% of the vascular volume.
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PMID:Blood and blood substitutes for treating hemorragic shock. 87 85

Experimental autoimmune hepatitis (EAH) has been induced in several strains of mouse by immunization with liver cytosol plus Freund's complete adjuvant. Our goal was to validate EAH in female C57Bl/6 mice and to compare the ability of immunization with liver cytosol and hepatocyte plasma membranes in Freund's complete (CFA) or incomplete (IFA) adjuvants to induce EAH. Control mice received Hank's balanced salt solution (HBSS), alone or an emulsion of HBSS in either CFA or IFA. The severity of hepatitis in coded liver sections was compared. EAH-like lesions were found not only in mice immunized with liver antigens in CFA or IFA but also in mice injected with either CFA or IFA. Mice injected with HBSS alone showed no hepatitis. These results indicate that immunization with neither liver nor mycobacteria cell wall antigens is required for induction of EAH-like lesions and suggest that the EAH in C57Bl/6 mice may be a nonspecific inflammatory response to adjuvant oil.
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PMID:Murine experimental autoimmune hepatitis: nonspecific inflammation due to adjuvant oil. 802 Jan 96