Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Comparative investigations were carried out on the antibody level in test animals--sheep, vaccinated with a polyvaccine against C and D enterotoxemia and necrotic hepatitis as well as in combined application with Levamisol. It was found that with the use of the preparation the stimulation of immunogenesis with type D and necrotic hepatitis--type B antigens (included in the composition of the polyvaccine) was enhanced. No stimulation of immunogenesis with the type C specific antigen was found within the period of investigation. Immunity was better built up when the animals were treated with the combined product as compared with the controls, given the polyvaccine without Levamisol.
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PMID:[Trials of immunostimulation of an antitoxic response with levamisole in the immunization of sheep with a combined clostridial vaccine]. 287 49

Mice experimentally infected with H. nana and injected with immunosuppressant {cyclophosphamide (Cp) and lead nitrate (Ln)} showed significant increase in infection intensity, significant decrease in intestinal mast cell count, dissemination of larvae to the liver, toxic hepatitis and absence of specific serum IgG. Cyclophosphamide caused morphological abnormallities in adult worms, prolongation of patent period and more severe villous changes. Immuno-stimulants represented by Levamisol (Lv) and gamma interferon (IFN-alpha) caused significant decrease in infection intensity, significant shortening of patent period and early improvement of histopathological changes. Immunostimulants, particularly IFN-alpha, were highly effective in counteracting hyperinfection seen with immuno-suppression. The study confirmed the deleterious effects of immunosuppression on hymenolepiasis and suggested a beneficial role for immunotherapy for immunosuppressed patients.
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PMID:Effect of some immunomodulators on the host-parasite system in experimental Hymenolepiasis nana. 1660 1