Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Anticonvulsant hypersensitivity syndrome caused by sodium valproate (Depakene) has rarely been reported. Here we describe a patient who presented with nonspecific polymorphous eruptions, fulminant hepatitis, and jaundice. Lichenoid dermatitis was found in the skin biopsy specimen. Toxic hepatitis and microvesicular steatosis were found in the liver biopsy specimen, consistent with valproate hepatotoxicity.
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PMID:Fatal sodium valproate-induced hypersensitivity syndrome with lichenoid dermatitis and fulminant hepatitis. 1289 87

The relationships between chronic liver diseases and trace heavy metal contents in blood are debatable and have not been understood clearly. The present study is undertaken to determine Co, Fe, and Ni concentrations in sera from viral hepatitis patients. In all eighty patients with chronic hepatitis (B, C) and 29 healthy individuals were chosen for this study. Donors were selected from different environmental areas, including Aswan, Kom Ombo, and Edfu as polluted areas, and Daraw as an unpolluted area. Co, Fe, and Ni concentrations in patient and healthy blood serum were measured by two different analytical techniques: differential pulse adsorptive stripping voltammetry (DPA(d)SV) and atomic absorption spectrophotometer (AAS). The results reveal that Fe is present in higher level in the blood serum of hepatitis patients than in the healthy control, whereas Co and Ni showed the opposite trend. Hepatitis patients from Edfu area exhibited higher Fe level in their serum than those from the other areas, while hepatitis patients and healthy control from Daraw area (free from pollution) exhibited the lowest metal values. Patients with hepatitis C show lower levels of Co, Ni, and Fe in their serum than those with hepatitis B. A comparative study was carried out between the results using DPA(d)SV and AAS techniques, which are in very good agreements.
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PMID:Trends in speciation analysis of some heavy metals in serum of patients with chronic hepatitis C and chronic hepatitis B using differential pulse adsorptive stripping voltammetric measurement and atomic absorption spectrophotometry. 2041 73

Depakote-induced hepatotoxicity has been well established as an adverse effect, and periodic monitoring of drug level is often required. Depakote-induced hepatotoxicity mostly occurs at supratherapeutic drug level. Rarely, an idiosyncratic response is triggered, and hepatotoxicity can occur at the therapeutic drug level mostly in chronic users. Here, we describe a rare case of idiosyncratic depakote-induced hepatotoxicity. A 25-year-old female with non-insulin-dependent diabetes mellitus, hypothyroidism, seizure disorder, and Dandy Walker Syndrome presented with an unwitnessed seizure and altered mental status. The patient's medication list included zonisamide, depakote, and synthroid. She was noted to be lethargic, disoriented, nonverbal, but awake. An arterial blood gas examination showed severe anion gap metabolic acidosis. Blood work was consistent with hepatitis, hyperammonemia, thrombocytopenia, and coagulopathy. The Depakote level was therapeutic. Head computed tomography and liver ultrasound results were not significant. After ruling out all other causes and seeing improvement of parameters after the drug was discontinued, idiosyncratic depakote toxicity was diagnosed. Based on the patient's rapid improvement; idiosyncratic valproate toxicity was confirmed. This case signifies the importance of recognizing, diagnosing, and treating depakote toxicity in chronic users who have no other explanation for their symptomatology.
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PMID:Thinking beyond the obvious: hepatotoxicity secondary to idiosyncratic depakote toxicity. 2124 13