Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Five case histories are presented of patients developing cholestatic hepatitis associated with the intake of the antibiotic combination agent amoxicillin and clavulanic acid (Augmentin). In two of these cases, signs of hepatic injury recurred after readministration of this combination but not after the intake of amoxicillin alone. In none of the patients was another cause for cholestatic hepatitis found and extrahepatic causes were excluded by ultrasonography, CT scanning, or ERCP. Most viral causes of hepatic injury were excluded in these patients. With the exception of one patient, who developed a transient rash, no immunoallergic signs were present. Biopsy in two patients showed extensive cholestasis without significant necrosis. Clavulanic acid seems to be responsible for this adverse effect.
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PMID:Cholestatic hepatitis due to antibacterial combination of amoxicillin and clavulanic acid (augmentin) 238 35

Two cases of reversible cholestatic hepatitis after treatment with an amoxycillin/clavulanic acid preparation (Augmentin) are described.
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PMID:Cholestatic hepatitis due to an amoxycillin/clavulanic acid preparation. 280 68

We described a patient with history of chronic hepatitis B in whom cholestatic hepatitis occurred after amoxicillin/clavulanic acid (Augmentin) therapy, which to our knowledge is the first case reported in Asia. An atypical serology profile of hepatitis B virus (HBV) markers, demonstrated by negative hepatitis B surface antigen (HBsAg) associated with transient positivity of hepatitis B e antigen (HBeAg) and HBV DNA, was noted during the development of cholestasis.
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PMID:Amoxicillin/clavulanic acid associated cholestasis in a patient with chronic hepatitis B: a case report. 771 97