Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To date several infectious agents have been proposed to cause KS, but none of these agents have been consistently demonstrated in KS. Epidemiologic studies suggest that host factors, including age, race, and sex, play an important role in KS. One hypothesis is that primary infection or activation of a latently infecting agent may play a role in KS; the other factors may be related to KS by activating such an agent. The 13 to 30 days between rug or carpet cleaning and onset of KS may represent an incubation or induction period for an infectious agent. The presence of certain epidemiologic risk factors and infectious agents in some outbreaks and not in others is puzzling (Table 4). Nevertheless, there are precedents for intermittently occurring epidemiologic risk factors, as with hepatitis, in which enteral and parenteral transmission can occur with the associated risk factors for each mode of transmission. The mechanisms by which the intermittently associated epidemiologic risk factors of antecedent illness and exposure to recently shampooed or spot-cleaned rugs or carpets relate to KS remain unknown. Similarly, how living near a body of water relates to KS awaits further clarification. The cause of KS remains a fascinating and controversial question, and the answer continues to grow in importance with the increasing health impact of this disease. As more data accumulate, high-dose IVIG therapy appears to brighten the outlook for KS patients as we await identification of the cause of this disease and more definitive treatment. Because we have just begun to use this therapy in KS, it is most important that any adverse effects that may occur be brought to the attention of the medical community. One question regarding KS will remain unanswered for years, that is, long-term sequelae of the disease in both treated and untreated patients. There have been a few anecdotal reports of onset of exertional angina in children several years after onset of KS. Histopathologic studies of coronary vessels of five KS patients who died of causes unrelated to KS and who apparently had completely recovered from the illness revealed abnormalities of the coronary vessels, primarily changes in the intima and internal elastic lamina. This has led to speculation that patients with a history of KS may have some coronary artery lesions not serious enough to be clinically detectable or to become an immediate cause of death but which may lead to juvenile arteriosclerosis.(ABSTRACT TRUNCATED AT 400 WORDS)
 ...
PMID:Kawasaki syndrome: issues in etiology and treatment. 264

Coronary bypass surgery is a palliative procedure and medical management after surgery is best provided by the private physician in cooperation with the surgical center. Whereas digitalis is rarely indicated in patients after bypass surgery, several prospective and randomized studies have shown that the early use of anticoagulants or platelet inhibiting agents improves graft patency after surgery. This medication should be given for about one year. Complex ventricular arrhythmias (Lown III-V) are 2-3 times as frequent 6-8 weeks after aortocoronary bypass surgery as before the operation. However, they are of less prognostic importance than similar arrhythmias occurring one year after surgery. Exercise-induced angina with ST segment depression occurs in 3% of patients per year with complete revascularization, as compared to 6-10% of patients/year with less than complete revascularization. Repeat angiography after surgery is performed if limiting angina recurs. In some instances coronary angioplasty may reestablish successful bypass surgery. Mortality and morbidity of reoperation are slightly higher and the success rate is slightly lower than with a first operation. Postoperative complications, such as post-pericardiotomy syndrome, left ventricular dysfunction and hepatitis, are briefly discussed.
 ...
PMID:[Postoperative care of coronary surgery patients]. 661 Sep 38

The condition of hemorheology and hemodynamics has been studied in patients with exertional angina (n = 20) and with effort angina presenting with concomitant chronic persisting hepatitis (n = 25). Coronary patients presenting with concurrent abnormalities of the hepatobiliary system displayed a significant reduction in the hepatic bloodflow resultant from a long-duration disorder of the liver and association of disturbances in the central hemodynamics and local autoregulatory mechanisms of compensation for intraorganic circulation.
 ...
PMID:[Central and regional hepatic hemodynamics in patients with ischemic heart disease and concomitant chronic persistent hepatitis]. 978 6

An antilipidemic effect of poseidonol was tested in 123 patients with ischemic heart disease, stable angina of effort (II-III functional class), 40 patients with secondary pyelonephritis and 40 patients with chronic hepatosis-hepatitis associated with chronic alcoholism or diabetes mellitus. The patients had also hyperlipidemia. A positive effect of poseidonol was established: cholesterol content fell by 25.4, 20.6 and 18.7%, respectively; triglycerides level decreased by 63, 42 and 21.4%, respectively; B-lipoproteins fell by 55.5, 36.9 and 13.1%, respectively. High density lipoproteins rose by 40.2, 27 and 69.9%, respectively. No adverse effects either on the liver or kidney functions were observed.
 ...
PMID:[Poseidonol in the treatment of patients with hyperlipidemia]. 1122 Aug 93